Results 91 to 100 of about 7,007,196 (291)

In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice

Frontiers in Pharmacology, 2018
Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Roberta Lattanzi, Silvia Rief, Helmut Schmidhammer, Lucia Negri, Mariana Spetea   +4 more
doaj   +1 more source

Access to Opioid Agonist Treatment during COVID-19 Project

, 2022
Data for methadone clinics, travel times, and census data used in "Access to Opioid Agonist Treatment during COVID-19 Public Transport Disruptions"
Higgins, Chrisopher D., Gupta, Kumar, Yücel, Shiv G., Palm, Matthew   +3 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Fentanyl assisted treatment: a possible role in the opioid overdose epidemic?

Substance Abuse Treatment, Prevention, and Policy, 2019
Background The current opioid overdose epidemic affecting communities across North America is increasingly driven by illicitly manufactured fentanyl and its related analogues.
Geoff Bardwell, Evan Wood, Rupinder Brar
doaj   +1 more source

Comportamento de coçar e nocicepção evidenciados após a aplicação facial de endotelina-1: um novo teste, uma nova oportunidade farmacológica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente trabalho reproduziu o modelo experimental descrito por Shimada e Lamotte, (2008), e o
Gomes, Lenyta Oliveira
core  

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Determining the impact of opioid substitution therapy upon mortality and recidivism among prisoners: a 22 year data linkage study [PDF]

, 2014
Foreword: Prisoners experience high rates of drug dependence, health problems and premature mortality. Without intervention, they often come into further contact with the criminal justice system, creating further health risk.
Natasa Gisev, Weatherburn, Don J., Burns, L., Lucy Burns, Louisa Degenhardt, Degenhardt, L., Gisev, Natasha, Mattick, R., Tony Butler, Weatherburn, Don, Kimber, J., Don Weatherburn, Kimber, Jo, Degenhardt, Louisa, Amy Gibson, Gisev, N., Larney, S ; https://orcid.org/, Gibson, Amy (R17420), Burns, Lucy, Larney, Sarah, Richard Mattick, Butler, Tony, Weatherburn, D., Dobbins, Tim, Gisev, N ; https://orcid.org/, Degenhardt, L ; https://orcid.org/, Tim Dobbins, Gibson, Amy, Weatherburn, D, Gibson, A., Mattick, RP, Larney, S., Gisev, Natasa, Jo Kimber, Dobbins, T ; https://orcid.org/, Mattick, Richard P., Dobbins, T., Sarah Larney, Kimber, J, Burns, L ; https://orcid.org/, Gibson, A ; https://orcid.org/, Butler, T ; https://orcid.org/, Dobbins, Timothy A., Mattick, Richard   +43 more
core   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

The effect of person, treatment and prescriber characteristics on retention in opioid agonist treatment: a 15‐year retrospective cohort study

, 2021
First published: 12 May 2021Background and Aims: There is limited evidence on the relationship between retention in opioid agonist treatment for opioid dependence and characteristics of treatment prescribers.
Barbieri, S., Natasa Gisev, Matthew Hickman, Louisa Degenhardt, Degenhardt, L., Hickman, M., Timothy Dobbins, Larney, S., Ali, R., Chrianna Bharat, Nicola R. Jones, Robert Ali, Bharat, C., Dobbins, T., Gisev, N., Sarah Larney, Jones, N.R., Sebastiano Barbieri   +17 more
core   +1 more source