Results 91 to 100 of about 292,142 (337)

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function [PDF]

, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
Canals Buj, M., Ellis, J., Milasta, S., Milligan, G., Pediani, J.D.   +4 more
core   +1 more source

Community pharmacists' practices and perspectives on deprescribing high‐risk psychotropic medicines: National survey findings

British Journal of Clinical Pharmacology, EarlyView.
Aim To explore the practices, confidence and perspectives of community pharmacists in deprescribing high‐risk psychotropic medicines, including opioid analgesics, benzodiazepine, gabapentinoids and medicinal cannabis. Methods An anonymous, cross‐sectional national online survey was conducted between January and April 2025 among Australian community ...
Monica Jung, Louisa Picco, Aili V. Langford, Rose Laing, Jana Dostal, Suzanne Nielsen   +5 more
wiley   +1 more source

The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users [PDF]

, 2016
Aims: Activation of PPARγ by pioglitazone (PIO) has shown some efficacy in attenuating addictive-like responses in laboratory animals. The ability of PIO to alter the effects of opioids in humans has not been characterized in a controlled laboratory ...
Alonzo, Banks, Begelow, Beitner-Johnson, Berger, Bhargava, Bland, Bush, Bussiere, Carr, Chang, Cone, Cooper, de Guglielmo, de Guglielmo, Dhalla, Eisenstein, Eisenstein, Eisenstein, Eng, Ferguson, Fraser, Gagnon, Garrido, Gelinas, Gillies, Hopkins, Hutchinson, Hutchinson, Hutchinson, Jeanne M. Manubay, Jermaine D. Jones, Johnston, Katz, Kielian, Kreutzberg, Ledeboer, Levine, Maria A. Sullivan, Marie-Claire, Martin, Mellon, Moreno, Nakajima, Narita, Pacifici, Pelvig, Roberto Ciccocioppo, Sandra D. Comer, Sarruf, Shanthi Mogali, Song, SPSS, Stoll, Stopponi, Stopponi, Strain, Sweitzer, Tawfik, Tontonoz, Verena E. Metz, Verkhratsky, Walker, Walker, Walsh, Walsh, Watkins, Watkins, Wightman, Woods, Wybran, Zacny, Zacny, Zacny, Zhang   +74 more
core   +1 more source

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

Bulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon, Jiyeong Hong, Hanbin Oh, Chi Hwan Lee, Ki Hun Kim   +4 more
wiley   +1 more source

Measuring treatment attrition at various stages of engagement in Opioid Agonist Treatment in Ontario Canada using a cascade of care framework

BMC Health Services Research, 2022
Background The cascade of care framework is an effective way to measure attrition at various stages of engagement in Opioid Agonist Treatment (OAT). The primary objective of the study was to describe the cascade of care for patients who have accessed OAT
Farah Tahsin, Kristen A. Morin, Frank Vojtesek, David C. Marsh   +3 more
doaj   +1 more source

Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System

Frontiers in Systems Neuroscience, 2022
Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
doaj   +1 more source

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]

, 2001
To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P., Chavkin, Charles, Gurevich, Vsevolod V., Kovoor, Abraham, Lowe, Janet   +4 more
core  

Adverse effects of opioids prescribed in opioid agonist treatment: a systematic review protocol

, 2023
Background: Opioid agonist treatment (OAT) comprises the use of opioid agonists to replace illicit street opioids and is the treatment of choice for individuals with opioid use disorder (OUD). We aim to systematically review the risk for any type of adverse effects of OAT in patients with opioid use disorder.Methods: We aim to inform evidence-based ...
Maximilian Meyer, Christian Appenzeller-Herzog, Marco Cattaneo, Lars G. Hemkens   +3 more
openaire   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Rescue Analgesia for Opioid-Dependent Individuals on Opioid Agonist Treatment during Hospitalization: Adherence to Guideline Treatment

European Addiction Research, 2023
Introduction: Opioid agonist treatment (OAT) is the first-line treatment for opioid use disorder (OUD). Simultaneously, opioids are essential medicines in acute pain management. The literature is scarce on acute pain management in individuals with OUD, and guidelines are controversial for patients on OAT.
Isabelle Arnet, Kenneth M. Dürsteler, Christine Jaiteh, Florian Grossmann, Kurt E. Hersberger   +4 more
openaire   +2 more sources