Protein Science, Volume 35, Issue 2, February 2026.Abstract Detergents provide essential membrane‐mimetic environments for studying G protein‐coupled receptors (GPCRs), but their molecular impact on receptor energetics remains incompletely understood. We combined ligand binding, thermostability measurements, and atomistic molecular dynamics to dissect detergent‐ versus ligand‐driven stabilization in a ...
James B. Bower +6 more
wiley +1 more source
Comparative effectiveness of missed dose protocols of opioid agonist treatment in British Columbia, Canada: protocol for a population-based target trial emulation. [PDF]
BMJ OpenMondol MH +11 more
europepmc +1 more source
Effective management of chronic lumbar back pain in five dogs using an erector spinae plane block
Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.Abstract This retrospective case series evaluates the use of the ultrasound‐guided erector spinae plane block for managing chronic lumbar pain in five dogs unresponsive to conventional systemic analgesia. Each patient received a bilateral erector spinae plane block at either the L2/L3 or L3/L4 level under general anaesthesia. The injectate consisted of
Nathalie Haslinger, Katrin Ertelt
wiley +1 more source
Reflections on Consciousness in Intensive Care
Acta Paediatrica, Volume 115, Issue 2, Page 275-284, February 2026.ABSTRACT Evaluating consciousness in intensive care is pivotal to relieving suffering with analgesic or sedative drugs and in prognosis and diagnoses. The usual clinical perspective is to equate consciousness with responsiveness, assuming functional motor responses and sympathetic activity of the patient. Clinical diagnoses of coma may be wrong in more
Michael Broomé, Tiit Mathiesen
wiley +1 more source
Barriers and facilitators to injectable opioid agonist treatment engagement within a structural vulnerability context: a qualitative study of patient experiences in Vancouver, Canada. [PDF]
Harm Reduct JMayer S +5 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 3, Page 505-519, February 2026.Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj +7 more
wiley +1 more source
Opioid agonist treatment and the process of injection drug use initiation
, 2019 María Luisa Mittal +7 more
openalex +2 more sources
Diabetic Medicine, Volume 43, Issue 2, February 2026.Abstract Aims This study assesses national trends and, socio‐demographic and clinical factors associated with polypharmacy and potentially in appropriate prescribing among people with type 2 diabetes in Scotland from 2012 to 2022. Methods Retrospective cohort study using nationwide data from the Scottish Care Information – Diabetes database ...
William Berthon +8 more
wiley +1 more source
Desirable treatment or a problematic drug scene? - An interview study of patients' and professionals' views on the risks and benefits of liberalized opioid agonist treatment. [PDF]
Harm Reduct JNordgren J, Richert T.
europepmc +1 more source