Results 41 to 50 of about 7,007,196 (291)

Effectiveness of buprenorphine in detoxification and naltrexone in relapse prevention of tramadol-dependent patients: A case series

Archives of Mental Health, 2021
Tramadol hydrochloride is a centrally acting synthetic analgesic drug. Its analgesic properties are weak agonist at mu- and kappa-opioid receptors, blockade of reuptake serotonin (5-HT), and norepinephrine at synaptic cleft inhibiting pain transmission ...
Vijaya Chandra Reddy Avula
doaj   +1 more source

Injectable opioid agonist treatment for opioid use disorder: a national clinical guideline [PDF]

Canadian Medical Association Journal, 2019
KEY POINTS In 2018, at least 4460 Canadians died from an opioid overdose, of which 94% were determined to be unintentional (accidental) overdoses. This represents a 9% increase in overdose deaths from 2017 and a 48% increase from 2016.[1][1] The recent emergence of street fentanyl, carfentanil ...
Nadia, Fairbairn, Josey, Ross, Michael, Trew, Karine, Meador, Jeff, Turnbull, Scott, MacDonald, Eugenia, Oviedo-Joekes, Bernard, Le Foll, Marie-Ève, Goyer, Michel, Perreault, Christy, Sutherland   +10 more
openaire   +2 more sources

A retrospective cohort study evaluating correlates of deep tissue infections among patients enrolled in opioid agonist treatment using administrative data in Ontario, Canada.

PLoS ONE, 2020
ObjectiveThe objective of this study was to evaluate the relationship between individual characteristics and deep tissue infections in patients enrolled in opioid agonist treatment in Ontario, Canada.MethodsA retrospective cohort study was conducted on ...
Kristen A Morin, Chad R Prevost, Joseph K Eibl, Michael T Franklyn, Alexander R Moise, David C Marsh   +5 more
doaj   +1 more source

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

Molecular Pain, 2016
Despite mu opioid receptor agonists are the cornerstones of moderate-to-severe acute pain treatment, their effectiveness in chronic pain conditions is controversial.
Nunzio Vicario PhD (cand), Rosalba Parenti PhD, Giuseppina Aricò PhD, Rita Turnaturi PhD, Giovanna Maria Scoto MS, Santina Chiechio PhD, Carmela Parenti PhD   +6 more
doaj   +1 more source

The Bilateral Effects of Sleep-Related Breathing Disorders and Opioid Agonist Use: A Vicious Cycle in Methadone Maintenance Clinics

Journal of Sleep Sciences, 2022
Substance use disorder is a critical social and health problem placing a tremendous burden on the country's health care system. Harm reductionpolicy focusing on using opioid agonist make up the majority of the maintenance treatment options.
Lahya Afshari Saleh, Seyed Kaveh Hojjat, Mahnaz Amini, hadi Asadpour   +3 more
doaj   +1 more source

The Role of Opioids on Motor Activity in Physio-pathological Conditions [PDF]

, 2009
To date, four principal classes of opioid peptide receptors, μ (MOP), κ (KOP), δ (DOP) and ORL- 1 (NOP) have been identified and cloned. The experimental and clinical importance of this receptor family has been amply demonstrated in many diseases ...
Mabrouk, Omar Sharif
core  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Effects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors

Scientific Reports, 2023
Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders.
Soichiro Ide, Toshitake Hirai, Takafumi Muto, Tomio Yamakawa, Kazutaka Ikeda   +4 more
doaj   +1 more source

National opioid pharmacotherapy statistics 2014 [PDF]

, 2015
Summary Dependence on opioid drugs is associated with a range of health and social problems that affect individual drug users, their family and friends, and the wider public.
Australian Institute of Health and Welfare
core  

Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

Pharmacology Research & Perspectives, 2021
Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan®).
Joshua C. Zamora, Hudson R. Smith, Elaine M. Jennings, Teresa S. Chavera, Varun Kotipalli, Aleasha Jay, Stephen M. Husbands, Alex Disney, Kelly A. Berg, William P. Clarke   +9 more
doaj   +1 more source