Results 1 to 10 of about 1,287,402 (286)

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor

Nature Communications
The endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li, Nathan D. Winters, Shubhi Pandey, Colten Lankford, Hannah M. Stoveken, Emery Smith, Chu-Ting Chang, Stefano Zucca, Louis Scampavia, Timothy Spicer, Kirill A. Martemyanov   +10 more
doaj   +1 more source

Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance

Molecular Pain, 2012
The age-dependency of opioid analgesia and tolerance has been noticed in both clinical observation and laboratory studies. Evidence shows that many molecular and cellular events that play essential roles in opioid analgesia and tolerance are actually age-
Zhao Jing, Xin Xin, Xie Guo-xi, Palmer Pamela, Huang Yu-guang   +4 more
doaj   +1 more source

Hepatoprotective effect of opioid peptides in stress [PDF]

Research Results in Pharmacology, 2019
Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress ...
Alexey V. Solin, Yury D. Lyashev, Nikolay V. Tsygan   +2 more
doaj   +3 more sources

Sleep deprivation changes thimet oligopeptidase (THOP1) expression and activity in rat brain

Heliyon, 2019
The consequences of sleep deprivation on memory, cognition, nociception, stress, and endocrine function are related to the balance of neuropeptides, with peptidases being particularly essential.
Bruna Visniauskas, Priscila S.R. Simões, Fernanda M. Dalio, Maria D.G. Naffah-Mazzacoratti, Vitor Oliveira, Sergio Tufik, Jair R. Chagas   +6 more
doaj   +1 more source

A genetically encoded biosensor reveals location bias of opioid drug action

bioRxiv, 2018
Opioid receptors (ORs) precisely modulate behavior when activated by native peptide ligands but distort behaviors to produce pathology when activated by non-peptide drugs.
M. Stoeber, D. Jullié, Braden T. Lobingier, T. Laeremans, J. Steyaert, P. Schiller, A. Manglik, M. von Zastrow   +7 more
semanticscholar   +1 more source

Bioactive Peptides: A Review [PDF]

International Journal Bioautomation, 2011
Bioactive peptides have been defined as specific protein fragments that have a positive impact on body functions and conditions and may ultimately influence health [79].
Shrikant Sharma, Raghvendar Singh, Shashank Rana   +2 more
doaj  

Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration

European Journal of Pharmacology, 2010
Stress is known to elicit pain relief, a phenomenon referred to as stress-induced analgesia. Based on stress parameters, opioid and non-opioid intrinsic pain inhibitory systems can be activated.
Drupad Parikh, Abdul Hamid, T. Friedman, K. Nguyen, A. Tseng, P. Marquez, K. Lutfy   +6 more
semanticscholar   +1 more source

Research Note: Morphine influences circulating and tissue concentrations of met-enkephalin and proenkephalin (PENK) expression and plasma concentrations of corticosterone in chickens

Poultry Science
: The effects of the administration of the opioid agonist, morphine, on plasma and tissue concentrations of Met-enkephalin were determined in 14 wk old female chickens.
Colin G. Scanes, Krystyna Pierzchała-Koziec   +1 more
doaj   +1 more source

Sex differences after chronic stress in the expression of opioid-, stress- and neuroplasticity-related genes in the rat hippocampus

Neurobiology of Stress, 2018
Opioid peptides and their receptors re-organize within hippocampal neurons of female, but not male, rats following chronic immobilization stress (CIS) in a manner that promotes drug-related learning.
Matthew Randesi, Yan Zhou, Sanoara Mazid, Shannon C. Odell, Jason D. Gray, J. Correa da Rosa, Bruce S. McEwen, Teresa A. Milner, Mary Jeanne Kreek   +8 more
doaj   +1 more source

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro

Cell Transplantation, 2006
We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, George D. Pappas   +3 more
doaj   +1 more source