Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. [PDF]
Cell Mol Neurobiol, 2021 Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the processing of three main precursors: proopiomelanocortin, proenkephalin, and prodynorphin.
Gupta A +8 more
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides [PDF]
Nature Communications, 2020 Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath +13 more
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Curr Med Chem, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Remesic M, Lee YS, Hruby VJ.
europepmc +6 more sources
Opioid Receptors in Immune and Glial Cells—Implications for Pain Control [PDF]
Frontiers in Immunology, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
doaj +4 more sources
Challenges and new opportunities for detecting endogenous opioid peptides in reward [PDF]
Addiction Neuroscience, 2022 The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway +2 more
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Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions [PDF]
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
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Non-Opioid Peptides Targeting Opioid Effects. [PDF]
Int J Mol Sci, 2021 Opioids are the most potent widely used analgesics, primarily, but not exclusively, in palliative care. However, they are associated with numerous side effects, such as tolerance, addiction, respiratory depression, and cardiovascular events. This, in turn, can result in their overuse in cases of addiction, the need for dose escalation in cases of ...
Kaczyńska K, Wojciechowski P.
europepmc +4 more sources
Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks [PDF]
The Journal of Poultry ScienceFreedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang +4 more
doaj +2 more sources
Influence of opioid peptides on human neutrophil apoptosis and activation in vitro [PDF]
Mediators of Inflammation, 2002 Background: It has been shown that cells of the immune system release opioid peptides and possess receptors for them. The concentrations of opioid peptides in the peripheral circulation rapidly increase during inflammation and acute stress response.
Zofia Sulowska +4 more
doaj +2 more sources
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor [PDF]
Nature CommunicationsThe endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li +10 more
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