Results 1 to 10 of about 1,287,964 (217)
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides [PDF]
Nature Communications, 2020 Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath +13 more
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Opioid Receptors in Immune and Glial Cells—Implications for Pain Control [PDF]
Frontiers in Immunology, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
doaj +4 more sources
Curr Med Chem, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Remesic M, Lee YS, Hruby VJ.
europepmc +5 more sources
Challenges and new opportunities for detecting endogenous opioid peptides in reward [PDF]
Addiction Neuroscience, 2022 The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway +2 more
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Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions [PDF]
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
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Biased signaling by endogenous opioid peptides. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance There are >20 different endogenous opioid peptides derived from the three precursors proopiomelanocortin, proenkephalin, and prodynorphin; a long-standing question is the biological utility of having this variety of peptides.
Gomes I +7 more
europepmc +2 more sources
Endogenous opioid peptides in the descending pain modulatory circuit. [PDF]
Neuropharmacology, 2020 The opioid epidemic has led to a serious examination of the use of opioids for the treatment of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the body. These receptors respond to endogenous opioid peptides that are
Bagley EE, Ingram SL.
europepmc +2 more sources
Non-Opioid Peptides Targeting Opioid Effects. [PDF]
Int J Mol Sci, 2021 Opioids are the most potent widely used analgesics, primarily, but not exclusively, in palliative care. However, they are associated with numerous side effects, such as tolerance, addiction, respiratory depression, and cardiovascular events. This, in turn, can result in their overuse in cases of addiction, the need for dose escalation in cases of ...
Kaczyńska K, Wojciechowski P.
europepmc +4 more sources
Food-Derived Opioid Peptides in Human Health: A Review. [PDF]
Int J Mol Sci, 2020 World Health Organization data suggest that stress, depression, and anxiety have a noticeable prevalence and are becoming some of the most common causes of disability in the Western world. Stress-related disorders are considered to be a challenge for the
Tyagi A +4 more
europepmc +2 more sources
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 In the mid-1970s, an intense race to identify endogenous substances that activated the same receptors as opiates resulted in the identification of the first endogenous opioid peptides.
Fricker LD +3 more
europepmc +2 more sources