Challenges and new opportunities for detecting endogenous opioid peptides in reward [PDF]
Addiction Neuroscience, 2022 The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway +2 more
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Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions [PDF]
Frontiers in Physiology, 2023 The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec +1 more
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Opioid Receptors in Immune and Glial Cells—Implications for Pain Control [PDF]
Frontiers in Immunology, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Halina Machelska, Melih Ö. Celik
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Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. [PDF]
Cell Mol Neurobiol, 2021 Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses. The three major endogenous opioid peptides, β-endorphin, enkephalins, and dynorphins result from the processing of three main precursors: proopiomelanocortin, proenkephalin, and prodynorphin.
Gupta A +8 more
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Curr Med Chem, 2016 For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Remesic M, Lee YS, Hruby VJ.
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Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]
PLoS Pathogens, 2009 In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner +9 more
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides [PDF]
Nature Communications, 2020 Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath +13 more
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Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain. [PDF]
Sci Rep, 2016 Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models.
Labuz D +3 more
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Influence of opioid peptides on human neutrophil apoptosis and activation in vitro [PDF]
Mediators of Inflammation, 2002 Background: It has been shown that cells of the immune system release opioid peptides and possess receptors for them. The concentrations of opioid peptides in the peripheral circulation rapidly increase during inflammation and acute stress response.
Zofia Sulowska +4 more
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Opioid peptide-derived analgesics [PDF]
The AAPS Journal, 2005 Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
Peter W. Schiller
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