Results 111 to 120 of about 18,798 (210)
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 Fricker LD +3 more
europepmc +1 more source
Obesity and Natural Products: Mechanisms, Therapeutic Potential, and Future Directions
Food Science &Nutrition, Volume 14, Issue 3, March 2026.Natural products such as EGCG, berberine, curcumin, and capsaicin modulate key metabolic pathways including AMPK activation, adipogenesis inhibition, and inflammatory signaling. While clinical trials demonstrate modest benefits on body weight and metabolic parameters, translational challenges related to bioavailability, dose feasibility, and regulatory
Ohoud M. Marie +1 more
wiley +1 more source
Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore. [PDF]
Molecules, 2020 Sarkar A +6 more
europepmc +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.ABSTRACT Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations.
Xiaofu Liu +32 more
wiley +1 more source
The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal
Addiction Biology, Volume 31, Issue 3, March 2026.Buprenorphine can either precipitate or relieve opioid withdrawal depending on the timing of administration relative to full opioid agonist exposure. The article proposes that buprenorphine promotes mu‐opioid receptor (MOR) externalization and resensitization, creating a temporary signaling gap that explains precipitated withdrawal when full agonists ...
Mehdi Haghdoost +6 more
wiley +1 more source
Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus. [PDF]
Molecules, 2020 Dyniewicz J +5 more
europepmc +1 more source
Addiction Biology, Volume 31, Issue 3, March 2026.This study contributes to understanding the health impacts of co‐occurring alcohol use disorder (AUD) and metabolic dysfunction (MD). Using clinical data from the NIH, individuals with both AUD and MD (metAUD) had the strongest associations with greater hepatic injury and inflammation, a less favorable liver function test profile, higher fibrosis ...
Alexandra C. Wagner +9 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1915-1923, March 2026.Abstract Aims Clinical guidelines recommend sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) for individuals with type 2 diabetes mellitus (T2DM) and established or high risk of cardiorenal disease. This study examined real‐world SGLT2i use patterns among older adults with T2DM in British Columbia, Canada.
Hanin Harbi +10 more
wiley +1 more source
Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence
Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 584-594, March 2026.Plain Language Summary While migraine headaches can be hard to predict, some patients believe headaches are connected to the moon‘s phases. Our research showed that migraine attacks were 34% more likely to occur during the new moon than during the full moon.
Alexander Yoo +5 more
wiley +1 more source