Receptor and blood-brain barrier characterization of opioid peptides in drug research and early development [PDF]
The penetration of the blood–brain barrier (BBB) combined with the receptor-subtype selectivity determines the medical activity of opioid peptides within the central nervous system (CNS).
Bracke, Nathalie+8 more
core +2 more sources
Abstract Background Methotrexate (MTX) is the mainstay initial treatment of rheumatoid arthritis (RA), but individual response varies and remains difficult to predict. The role of genetics remains unclear, but studies suggest its importance. Methods Incident RA patients starting MTX‐monotherapy were identified through a large‐scale Swedish register ...
Anton Öberg Sysojev+10 more
wiley +1 more source
Mobility-GCN: a human mobility-based graph convolutional network for tracking and analyzing the spatial dynamics of the synthetic opioid crisis in the USA, 2013-2020 [PDF]
Synthetic opioids are the most common drugs involved in drug-involved overdose mortalities in the U.S. The Center for Disease Control and Prevention reported that in 2018, about 70% of all drug overdose deaths involved opioids and 67% of all opioid-involved deaths were accounted for by synthetic opioids.
arxiv
Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash+5 more
wiley +1 more source
The Hidden Toll of COVID-19 on Opioid Mortality in Georgia: A Bayesian Excess Opioid Mortality Analysis [PDF]
COVID-19 has had a large scale negative impact on the health of opioid users exacerbating the health of an already vulnerable population. Critical information on the total impact of COVID-19 on opioid users is unknown due to a lack of comprehensive data on COVID-19 cases, inaccurate diagnostic coding, and lack of data coverage.
arxiv
Enteric neuropathy and the vagus nerve: Therapeutic implications
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley +1 more source
Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus. [PDF]
Dyniewicz J+5 more
europepmc +1 more source
Diet-ODIN: A Novel Framework for Opioid Misuse Detection with Interpretable Dietary Patterns [PDF]
The opioid crisis has been one of the most critical society concerns in the United States. Although the medication assisted treatment (MAT) is recognized as the most effective treatment for opioid misuse and addiction, the various side effects can trigger opioid relapse.
arxiv
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Bibliometric Analysis of the 50 Most Cited Publications in Epidermolysis Bullosa
ABSTRACT Epidermolysis bullosa (EB) is a group of inherited skin disorders characterized by extreme skin fragility, leading to recurrent blistering and significant impacts on patients' quality of life. A bibliometric analysis of the 50 most‐cited EB articles from the past six decades reveals that the majority of research focuses on understanding EB ...
Evelyn F. Fagan+4 more
wiley +1 more source