Results 151 to 160 of about 46,704 (314)

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Novel Opioid Peptide Derived Antagonists Containing (2S)-2-Methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic Acid [(2S)-Mdcp]

, 2008
Animesh Ghosh, Jie Luo, Chen Liu, Grazyna Weltrowska, Carole Lemieux, Nga N. Chung, Yixin Lü, Peter W. Schiller   +7 more
openalex   +2 more sources

Assessment of Pain Types in Recently Diagnosed Patients With Inflammatory Arthritis

Arthritis Care &Research, Volume 78, Issue 1, Page 154-163, January 2026.
Objective Up to 40% of patients with inflammatory arthritis (IA) experience persistent pain, traditionally thought to be associated with a shift from peripherally to centrally mediated pain during the disease course in some patients. We assessed sensory profiles of recently diagnosed individuals with IA, hypothesizing that pain reported at this early ...
Zoe Rutter‐Locher, Sam Norton, Joseph L. Taylor, Bina Menon, Tom Esterine, Ruth Williams, Leonie S. Taams, Kirsty Bannister, Bruce W. Kirkham   +8 more
wiley   +1 more source

Ingestion of Amniotic Fluid Enhances\ud Opiate Analgesia in Rats [PDF]

, 1986
Placenta ingestion has recently been shown to enhance opiate-mediated analgesia produced by morphine injection, footshock, or vaginal/cervical stimulation.
Abbott, Patricia, Kristal, Dr. Mark B., Thompson, Alexis C.   +2 more
core  

Design of Analgesic Trivalent Peptides with Low Withdrawal Symptoms: Probing the Antinociceptive Profile of Novel Linear and Cyclic Peptides as Opioid Pan Ligands

, 2023
Azzurra Stefanucci, Paola Minosi, Stefano Pieretti, Parthasaradhireddy Tanguturi, G Molnár, Giuseppe Scioli, Lorenza Marinaccio, Alice Della Valle, John M. Streicher, Adriano Mollica   +9 more
openalex   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Manual Therapy as Endogenous Opioid Modulator: A Theoretical Framework for Addiction Recovery Research

Psychiatry International
The global opioid crisis necessitates innovative non-pharmacological interventions for pain management and addiction recovery. This comprehensive narrative review synthesizes evidence from approximately 75 studies supporting manual therapy’s modulation ...
Hyunjoong Kim
doaj   +1 more source

Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]

Mol Pharmacol, 2020
Fricker LD, Margolis EB, Gomes I, Devi LA.   +3 more
europepmc   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore. [PDF]

Molecules, 2020
Sarkar A, Adamska-Bartlomiejczyk A, Piekielna-Ciesielska J, Wtorek K, Kluczyk A, Borics A, Janecka A.   +6 more
europepmc   +1 more source