Results 171 to 180 of about 1,122,610 (333)

Conceptual Density Functional Theory Study of the Chemical Reactivity Properties and Bioactivity Scores of the Leu-Enkephalin Opioid Peptide Neurotransmitter

, 2019
Juan Frau, Norma Flores-Holguı́n, Daniel Glossman‐Mitnik   +2 more
openalex   +2 more sources

Design of Analgesic Trivalent Peptides with Low Withdrawal Symptoms: Probing the Antinociceptive Profile of Novel Linear and Cyclic Peptides as Opioid Pan Ligands

, 2023
Azzurra Stefanucci, Paola Minosi, Stefano Pieretti, Parthasaradhireddy Tanguturi, G Molnár, Giuseppe Scioli, Lorenza Marinaccio, Alice Della Valle, John M. Streicher, Adriano Mollica   +9 more
openalex   +2 more sources

Gαs defines the fundamental coupling mechanism of insulin secretion

Journal of Diabetes Investigation, EarlyView.
Jun Shirakawa
wiley   +1 more source

Glucagon‐like peptide‐1 receptor agonist and respiratory complications after endoscopy: A Japanese nationwide cohort study

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 316-323, January 2026.
Abstract Aims While discontinuation of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) before esophagogastroduodenoscopy (EGD) is not universally mandated, safety concerns persist. Evidence remains insufficient for managing specific patient subgroups, particularly in Asian populations. We aimed to provide evidence for stratified risk assessment in
Hiroyuki Hisada, Kazuhiko Ikeuchi, Yosuke Tsuji, Nobutake Yamamichi, Naomi Kakushima, Kazuya Okushin, Seiichi Yakabi, Chihiro Takeuchi, Daisuke Ohki, Hiroya Mizutani, Yuko Miura, Dai Kubota, Takeya Tsutsumi, Mitsuhiro Fujishiro   +13 more
wiley   +1 more source

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus. [PDF]

Molecules, 2020
Dyniewicz J, Lipiński PFJ, Kosson P, Bochyńska-Czyż M, Matalińska J, Misicka A.   +5 more
europepmc   +1 more source

A Theory of Natural Addiction [PDF]

Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Attila Tasnádi, Trenton G. Smith
core  

Post‐tetanic depression of spinal reflexes in the rabbit and the possible involvement of opioid peptides.

, 1984
D. M. Catley, R.W. Clarke, Judith Pascoe
openalex   +2 more sources

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, Volume 47, Issue 12, December 2025.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists. [PDF]

, 1992
Peter W. Schiller, Tin Nguyen, Grazyna Weltrowska, Brian C. Wilkes, Brian J. Marsden, C. Lemieux, Nga N. Chung   +6 more
openalex   +1 more source