Results 171 to 180 of about 46,704 (314)
Food Science &Nutrition, Volume 14, Issue 1, January 2026.The Morchella mycelium polysaccharide (MP), a homogeneous α‐glucan (96.555% glucose, 5.7 kDa), protects against alcohol‐induced liver injury in mice. It reduces serum ALT/AST, improves lipid metabolism, and enhances antioxidants and inhibiting lipid peroxidation. Mechanistically, the MP suppresses Nlrp3 inflammasome‐mediated inflammation/pyroptosis and
Xinyu Hu +10 more
wiley +1 more source
Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia. [PDF]
J Pain, 2020 Sapio MR +7 more
europepmc +1 more source
Hippocampus, Volume 36, Issue 1, January 2026.ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley +1 more source
A Theory of Natural Addiction [PDF]
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Attila Tasnádi, Trenton G. Smith
core
Spirocyclic Diamine Scaffolds for Medicinal Chemistry
Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel +3 more
wiley +1 more source
Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.ABSTRACT Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage‐gated Ca2+ channel inhibition or G protein inwardly rectifying K+ channel activation. One mechanism of G protein‐coupled receptor (GPCR) desensitization occurs when G protein‐coupled receptor kinases (GRK ...
Mohamed Farrag +6 more
wiley +1 more source
Fentanyl exposure during preconception and gestation permanently dysregulates endogenous opioid peptides and sympathoadrenal-medullary axis in the offspring. [PDF]
Clin Sci (Lond)Ahmed N +8 more
europepmc +1 more source