Results 181 to 190 of about 1,122,610 (333)

MiR‐33‐5p‐opioidergic Signaling Regulates Cognitive Impairment Induced by Bile Duct Ligation in Rats: Ameliorative Role of Naloxone

Brain and Behavior, Volume 15, Issue 12, December 2025.
Bile‐duct ligation (BDL)‐induced memory impairment has a molecular, electrophysiological and histopathological basis and might be regulated by miR‐33‐opioid signaling. The modulation of miR in the brain may be a novel therapeutic approach for relieving neuropathological problems in cholestatic cases, and individuals with cholestasis may benefit from ...
Mohadeseh Rahimi‐vala, Behrang Alani, Ali Arjmand, Tahere Mazoochi, Abolfazl Ardjmand   +4 more
wiley   +1 more source

Continuous production of a peptidic fraction containing the intermediate opioid peptide LVV‐haemorphin‐7 (LVVh‐7) by peptic hydrolysis of bovine haemoglobin in a continuous membrane reactor

, 2003
Romain Kapel, Rénato Froidevaux, Naïma Nedjar‐Arroume, Anne Fertin‐Bazus, Pascal Dhulster, Didier Guillochon   +5 more
openalex   +2 more sources

Association of Ticagrelor Metabolic SNPs With Adverse Drug Reactions in Patients With Acute Coronary Syndrome

Clinical Cardiology, Volume 48, Issue 12, December 2025.
The CYP3A5 rs776746 CC genotype is a strong biomarker for ticagrelor‐induced dyspnea, conferring a 2.3‐fold higher risk. Genotype‐guided antiplatelet therapy may mitigate this adverse reaction, enabling personalized treatment for ACS patients. ABSTRACT Background Dual antiplatelet therapy with aspirin and a P2Y₁₂ inhibitor is standard for patients with
Yanming Zhang, Gaoxiu Yu, Cong Wang, Jingwen Song, Junmei Liu, Feng Chen   +5 more
wiley   +1 more source

One‐Pot Synthesis of Novel β‐Carboline‐{α‐Acylaminoamide}‐Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies

ChemistryOpen, Volume 14, Issue 12, December 2025.
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Ankit Kumar Atri, Lavanya Khullar, Gobind Kumar, Sahil Mishra, Tamanna Dua, Vinay Singh, Kusum Harjai, Parvesh Singh, Vasundhara Singh   +8 more
wiley   +1 more source

Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia. [PDF]

J Pain, 2020
Sapio MR, Iadarola MJ, Loydpierson AJ, Kim JJ, Thierry-Mieg D, Thierry-Mieg J, Maric D, Mannes AJ.   +7 more
europepmc   +1 more source

Novel Opioid Peptide Derived Antagonists Containing (2S)-2-Methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic Acid [(2S)-Mdcp]

, 2008
Animesh Ghosh, Jie Luo, Chen Liu, Grazyna Weltrowska, Carole Lemieux, Nga N. Chung, Yixin Lü, Peter W. Schiller   +7 more
openalex   +2 more sources

Osteoblastic metastasis secondary to mammary carcinoma in a dog (Canis lupus familiaris) presenting with lameness

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract Osteoblastic metastases occur secondary to malignant epithelial tumours, and lead to marked periosteal hyperostosis and medullary sclerosis. These are rarely reported in dogs. A 7‐year‐old, neutered, female labrador retriever × standard poodle presented with a 4‐week history of progressive right hindlimb lameness, pyrexia and thoracolumbar ...
David Sheehan, Benoit Cuq, Conor Moloney, Seamus Hoey, Oliver Waite, Hanne Jahns   +5 more
wiley   +1 more source

Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion

European Journal of Neuroscience, Volume 62, Issue 11, December 2025.
ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Maria Ciscato, Mathilde Chouvaeff, Alexandre Mourot   +2 more
wiley   +1 more source

Prescription of Monoclonal Antibodies Against Calcitonin Gene‐Related Peptide for the Prophylaxis of Migraine in Austria: A Retrospective, Longitudinal Analysis of Nationwide Insurance Data

European Journal of Neurology, Volume 32, Issue 12, December 2025.
In this retrospective, longitudinal study based on nationwide insurance data, of 8.8 million persons 8934 persons received at least one antibody against calcitonin gene‐related peptide or its receptor (CGRP‐mAb) within 49 months. Median therapy duration was 297 days.
Karin Zebenholzer, Andreas Gleiss, Berthold Reichardt, Walter Gall, Christian Wöber   +4 more
wiley   +1 more source

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems [PDF]

, 2016
Daniela da Fonseca Pacheco, Ana Cristina Nogueira Freitas, Adriano M.C. Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima   +4 more
openalex   +1 more source