Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain [PDF]
, 2016 Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models.
Celik, Melih O. +3 more
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In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides
Foods, 2020 Currently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known.
Lourdes Amigo +2 more
doaj +1 more source
In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
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Molecules, 2020 The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt +7 more
doaj +1 more source
Peripherally Acting Opioids in Orofacial Pain
Frontiers in Neuroscience, 2021 The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu +10 more
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Opioid peptides and metabolic regulation [PDF]
Diabetologia, 1988 La liaison entre opioides et obesite pourrait passer par des anomalies de l'insulino-secretion puisque une augmentation de la sensibilite des cellules B pancreatiques a la beta-endorphine a ete demontree chez les sujets obeses. Une profonde alteration du systeme opioide est presente dans le diabete sans que l'on puisse dire encore si cela represente un
GIUGLIANO, Dario +3 more
openaire +4 more sources
Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]
, 2016 Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor +18 more
core +1 more source
Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. [PDF]
PLoS ONE, 2011 It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling.
Li He, Jennifer L Whistler
doaj +1 more source
Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance
Frontiers in Cellular Neuroscience, 2019 Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan +6 more
doaj +1 more source
Neuroimmune Interaction in the Regulation of Peripheral Opioid-mediated Analgesia in Inflammation
Frontiers in Immunology, 2016 Peripheral immune-cell-mediated analgesia in inflammation is an important endogenous mechanism of pain control. Opioid receptors localized on peripheral sensory nerve terminals are activated by endogenous opioid peptides released from immune cells to ...
Susan Hua
doaj +1 more source