In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]
, 2018 Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta +4 more
core +2 more sources
Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. [PDF]
PLoS ONE, 2011 It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling.
Li He, Jennifer L Whistler
doaj +1 more source
Health related effects of wheat varieties [PDF]
, 2020 Summarises the different effects wheat digestion has on human ...
Borgen, Anders
core
Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides [PDF]
, 2015 Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ...
Beaudry, Francis, Saidi, Mouna
core +1 more source
Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance
Frontiers in Cellular Neuroscience, 2019 Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan +6 more
doaj +1 more source
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
An update on the potential for male contraception : emerging options [PDF]
, 2013 The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women.
Alsaadi, Manal +5 more
core +1 more source
Rubsicolins are naturally occurring G-protein-biased delta opioid receptor peptides
bioRxiv, 2018 The impact that β-arrestin proteins have on G-protein-coupled receptor trafficking, signaling and physiological behavior has gained much appreciation over the past decade.
Robert J. Cassell +6 more
semanticscholar +1 more source
Neuroimmune Interaction in the Regulation of Peripheral Opioid-mediated Analgesia in Inflammation
Frontiers in Immunology, 2016 Peripheral immune-cell-mediated analgesia in inflammation is an important endogenous mechanism of pain control. Opioid receptors localized on peripheral sensory nerve terminals are activated by endogenous opioid peptides released from immune cells to ...
Susan Hua
doaj +1 more source
Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]
, 2016 Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor +18 more
core +1 more source