Results 51 to 60 of about 45,822 (323)
Advanced Healthcare Materials, EarlyView.Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao +2 more
wiley +1 more source
Perspectives on Endogenous Opioids in Birds
Frontiers in Physiology, 2018 The present review summarizes the state of knowledge of endogenous opioids in birds. Endogenous opioid peptides acts in a neuromodulatory, hormonal and paracrine manner to mediate analgesic and other physiological functions.
Colin G. Scanes +1 more
doaj +1 more source
Bioactive Peptides in Milk and Milk products, Antimicrobial Properties and Effects on Human Health
Turkish Journal of Agriculture: Food Science and Technology, 2020 In recent years, apart from the nutritional values of foods, functional properties have also gained importance. Bioactive peptides are the fragmentation products of proteins that have a positive effect on human health.
Selda Bulca, Burcu Güvenç
doaj +1 more source
Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary [PDF]
, 1982 A 4,000-dalton dynorphin was isolated from porcine pituitary. It has 32 amino acids (Mr = 3,986), with the previously described heptadecapeptide (now called dynorphin A) at its amino terminus and a related tridecapeptide, dynorphin B, at its carboxyl ...
Fischli, Walter +3 more
core
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]
, 2020 Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG +7 more
core
An update on the potential for male contraception : emerging options [PDF]
, 2013 The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women.
Alsaadi, Manal +5 more
core +1 more source
Advanced Science, EarlyView.This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein +9 more
wiley +1 more source
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]
, 2015 Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia +112 more
core +5 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside +5 more
wiley +1 more source