Results 71 to 80 of about 18,798 (210)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini +9 more
wiley +1 more source
Cell Transplantation, 2006 We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya +3 more
doaj +1 more source
Platelet‐Rich Fibrin Can Improve Septoplasty Results: A Prospective Randomised Controlled Trial
Clinical Otolaryngology, EarlyView.ABSTRACT Aim This study aims to assess the impact of platelet‐rich fibrin (PRF) on nasal mucociliary clearance (NMC) time and post‐operative pain following septoplasty. Patients and Methods This trial was conducted involving patients who underwent septoplasty. Participants were randomly assigned to either a control group or a PRF group.
Emre Solguntekin +3 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims To evaluate the effectiveness of combination therapy with sodium‐glucose cotransporter 2 (SGLT‐2) inhibitors and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) compared with continued SGLT‐2 inhibitor therapy in routine practice among individuals with type 2 diabetes.
Gregor A. Maier +3 more
wiley +1 more source
Molecular docking study of Papaver alkaloids to some alkaloid receptors [PDF]
Research Journal of Pharmacognosy, 2017 Background and objectives: More than 40 different alkaloids have been obtained from opium the most important of which are morphine, codeine, papaverine, noscapine and tabaine.
A. Nofallah +3 more
doaj
The life and times of endogenous opioid peptides: Updated understanding of synthesis, spatiotemporal dynamics, and the clinical impact in alcohol use disorder. [PDF]
Neuropharmacology, 2023 Margolis EB +3 more
europepmc +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen +6 more
wiley +1 more source
In Vivo Regulation of the μ Opioid Receptor: Role of the Endogenous Opioid Agents
Molecular Medicine, 2013 It is well known that genotypic differences can account for the subject-specific responses to opiate administration. In this regard, the basal activity of the endogenous system (either at the receptor or ligand level) can modulate the effects of ...
Veronica Gonzalez-Nunez +3 more
doaj +1 more source
Regulation of Opioid Receptors by Their Endogenous Opioid Peptides. [PDF]
Cell Mol Neurobiol, 2021 Gupta A +8 more
europepmc +1 more source