Results 81 to 90 of about 1,122,610 (333)

A Theory of Natural Addiction [PDF]

, 2007
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie, Atkinson, Attila Tasnádi, Baldwin, Baron-Cohen, Becker, Becker, Bergstrom, Blass, Blass, Blass, Bodnar, Booth, Brick, Camerer, Camerer, Campbell, Carson-DeWitt, Chiara, Cohen, Colantuoni, Cooper, Cooper, Cummings, Deth, Drewnowski, Dudley, Dum, Fantino, Fehr, Foster, Gilbertson, Gillberg, Gosnell, Griffiths, Grossman, Gruber, Gul, Harrigan, Headlee, Hirshleifer, Hirshleifer, Holtzman, Jaffe, Kahneman, Kalat, Kavaliers, Kavaliers, Killian, Laibson, Laibson, Leboyer, Leboyer, Loewenstein, Martin, McKim, Mello, Mercer, Morley, Mucha, Mucha, Nelson, Nesse, Nesse, Orphanides, Orphanides, Ostrowski, Parfitt, Pert, Pomerleau, Raiten, Raven, Robson, Rogers, Rudski, Samuelson, Sanger, Savage, Schuckit, Si, Simon, Simpkins, Smith, Sozou, Spanagel, Sullivan, Sullivan, ter Riet, Terenius, Trenton G. Smith, van Ree, van Ree, van Ree, Waeltl, Weeks, Weeks, Weiss, Williams, Yamamoto, Yeomans, Yeomans, Yeomans, Zigmond   +102 more
core   +1 more source

Photoswitchable Peptides as Molecular Tools to Encode Structural Order and Disorder in Intracellular Assemblies

Angewandte Chemie International Edition, EarlyView.
We present a photoswitchable peptide conjugate which exhibits isomerism‐dependent self‐assembly: the planar trans‐isomer assembles into well‐ordered nanofibers while the non‐planar cis‐isomer yields disordered aggregates. Our study offers a direct visualization on the effects of structure formation inside living cells.
Julian Link, Luca Burg, Sarah Chagri, Ha‐Chi Nguyen, David Y.W. Ng, Bart Jan Ravoo, Tanja Weil   +6 more
wiley   +1 more source

Hemorphins—From Discovery to Functions and Pharmacology

Molecules, 2021
During the last three decades, a variety of different studies on bioactive peptides that are opioid receptor ligands, have been carried out, with regard to their isolation and identification, as well as their molecular functions in living organisms. Thus,
Przemyslaw Mielczarek, Kinga Hartman, Anna Drabik, Hao-Yuan Hung, Eagle Yi-Kung Huang, Ewa Gibula-Tarlowska, Jolanta H. Kotlinska, Jerzy Silberring   +7 more
doaj   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference

Pharmaceuticals, 2023
The macrocyclic tetrapeptide CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) and its D-Trp isomer exhibit kappa opioid receptor (KOR) antagonism which prevents stress-induced reinstatement of extinguished cocaine-conditioned place preference. Here, we evaluated the
Kristen H. Scherrer, Shainnel O. Eans, Jessica M. Medina, Sanjeewa N. Senadheera, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich   +7 more
doaj   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Pharmacological Preconditioning: Role of Opioid Peptides

Общая реаниматология, 2012
The review deals with the mechanisms of action of opioids and the synthetic analogue of endogenous leuenkephaline dalargin. It discusses the relation of delta-opioid receptors to the phenomenon of pharmacological preconditioning that may explain the ...
V. V. Likhvantsev, O. A. Grebenchikov, A. A. Shaposhnikov, K. Yu. Borisov, R. A. Cherpakov, N. M. Shulgina   +5 more
doaj   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

Chemistry &Biodiversity, EarlyView.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper, Daniela Hemsing, Julia Elisabett K. Bolsonello, Susana R. de Mello Schlemper, Tiago Tizziani, Lutuima A. Capangue Neto, Louis P. Sandjo   +6 more
wiley   +1 more source

Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance

Molecular Pain, 2012
The age-dependency of opioid analgesia and tolerance has been noticed in both clinical observation and laboratory studies. Evidence shows that many molecular and cellular events that play essential roles in opioid analgesia and tolerance are actually age-
Zhao Jing, Xin Xin, Xie Guo-xi, Palmer Pamela, Huang Yu-guang   +4 more
doaj   +1 more source

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources