Mammalian Tolerance to Amino Acid Heterochirality
ChemBioChem, EarlyView.Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi +4 more
wiley +1 more source
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo [PDF]
, 1986 Geoffrey C. Kirby, Daniel S. McQueen
openalex +1 more source
Speaking of Stigma: Piloting Language Training in Addiction Counseling Coursework
Counselor Education and Supervision, EarlyView.ABSTRACT This pilot study examined counselor‐in‐training (CIT) attitudes and awareness regarding stigma and stigmatizing language aimed at those with substance use disorders before and after an author‐developed educational intervention. Results indicated this intervention positively impacted CIT awareness and attitudes and their ability to identify and
Amy L. Grybush +2 more
wiley +1 more source
Monoclonal antibody to the message sequence Tyr-Gly-Gly-Phe of opioid peptides exhibits the specificity requirements of mammalian opioid receptors. [PDF]
, 1983 T Meo +6 more
openalex +1 more source
Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities
ChemMedChem, EarlyView.Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia +4 more
wiley +1 more source
Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]
, 2018 The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E +4 more
core
The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]
, 2020 The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III +2 more
core +1 more source
ChemPhysChem, EarlyView.Drug repositioning of lidocaine from local anesthetic to theranostic agent for breast cancer cells is enhanced by its encapsulation inside ZIF‐8 metal–organic framework. The aim of this article is to use zeolitic imidazolate framework‐8 (ZIF‐8) metal–organic frameworks (MOFs) as drug delivery system for lidocaine, a local anesthetic with recently ...
Nicola di Nicola +7 more
wiley +1 more source
In-vivo studies on kappa opioid receptors [PDF]
, 1986 Alan Cowan, Debra E. Gmerek
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient‐facing portal that delivers multi‐gene PGx results (CYP2D6, UGT1A1, DPYD) through ...
Youngwoo Cho +15 more
wiley +1 more source