Results 151 to 160 of about 2,594,817 (409)
The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist
Translational Psychiatry, 2014 Current pharmacological treatments of depression and related disorders suffer from major problems, such as a low rate of response, slow onset of therapeutic effects, loss of efficacy over time and serious side effects.
Madalee Gassaway +4 more
semanticscholar +1 more source
Machine learning methods for predicting adverse drug events: A systematic review
British Journal of Clinical Pharmacology, EarlyView.Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo +8 more
wiley +1 more source
Buprenorphine in Neonatal Abstinence Syndrome. [PDF]
, 2018 Infants exposed in utero to opioids will demonstrate a withdrawal syndrome known as neonatal abstinence syndrome (NAS). Buprenorphine is a long-acting opioid with therapeutic use in medication-assisted treatment of opioid dependency in adults and ...
Kraft, Walter K.
core +1 more source
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The purpose of the present investigation was to determine the effects of combination of Ormenis multicaulis dry flower methanolic extracts and Carum carvi seed methanolic extracts on pain and inflammation, compared to their use separately. High‐performance liquid chromatography (HPLC) analysis of methanolic extracts showed the presence of ...
El Mahdi Wakrim +9 more
wiley +1 more source
The biopsychology of maternal behavior in nonhuman mammals [PDF]
, 1990 The term “maternal behavior,” when applied to nonhuman mammals, includes the behaviors exhibited in preparation for the arrival of newborn, in the care and protection of the newly arrived young, and in the weaning of those young, and represents a complex
Kristal, Dr. Mark B.
core
Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies [PDF]
, 2011 Mariana Spetea +11 more
openalex +1 more source
Chemistry &Biodiversity, EarlyView.Pharmacological investigation of the aqueous extract of Annona muricata L. leaves from Indonesia. ABSTRACT This study investigates, for the first time, the comprehensive pharmacological profile of the aqueous extract of Annona muricata L. (graviola) leaves from Indonesia, focusing on its antioxidant, antinociceptive, and anti‐inflammatory properties ...
Sara Oufquir +8 more
wiley +1 more source
Selective up‐regulation of functional mu‐opioid receptor splice variants by chronic opioids [PDF]
, 2015 Sumita Chakrabarti +2 more
openalex +1 more source
Opioid and Nitrergic Pathways Mediate Antinociception by Pectis elongata Kunth. Essential Oil
Chemistry &Biodiversity, EarlyView.ABSTRACT In the present study, we aimed to evaluate the antinociceptive potential of the Pectis elongata essential oil (PeEO) and to understand its mechanism of action by identifying possible pain inhibition pathways. PeEO was analyzed using gas chromatography coupled with mass spectrometry.
Angela Palma Amorin +8 more
wiley +1 more source