Results 111 to 120 of about 2,447,948 (384)
Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala [PDF]
Research Results in Pharmacology 10(1): 1-6 (2024)Introduction: Kappa-opioid receptor (KOR) signaling in the basolateral amygdala (BLA) underlies KOR agonist-induced aversion. In this study, we aimed to understand the individual and combined effects of KOR agonist U-50488 and p38 MAPK inhibitor SB203580 on the spiking activity of pyramidal neurons in the BLA to shed light on the complex interplay ...
arxiv +1 more source
κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance
Journal of Neuroscience, 2012 The prairie vole is a socially monogamous species in which breeder pairs typically show strong and selective pair bonds. The establishment of a pair bond is associated with a behavioral transition from general affiliation to aggressive rejection of novel
Shanna Resendez +3 more
semanticscholar +1 more source
Towards Better Opioid Antagonists Using Deep Reinforcement Learning [PDF]
arXiv, 2020 Naloxone, an opioid antagonist, has been widely used to save lives from opioid overdose, a leading cause for death in the opioid epidemic. However, naloxone has short brain retention ability, which limits its therapeutic efficacy. Developing better opioid antagonists is critical in combating the opioid epidemic.Instead of exhaustively searching in a ...
arxiv
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
Nature Communications, 2020 Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and stress by activating opioid receptors, currently classified into four subtypes. Here we demonstrate that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for
M. Meyrath +13 more
semanticscholar +1 more source
Genome Biology, 2001 Mouse μ-opioid receptor carboxy-terminal splice variants have been shown to differ in their responses to agonists.
openaire +2 more sources
Straub tail, the deprivation effect and addiction to aggression [PDF]
arXiv, 2006 It has been observed that male mice who are consistently winning fights with conspecifics can raise their tail, which is very similar to a morphine-induced Straub tail response. Since this response is a typical index of opiate activation, it has been proposed that the opioidergic systems of such mice are chronically activated.
arxiv
Structural insights into μ-opioid receptor activation
Nature, 2015 Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X-ray crystal structure of the murine μOR bound to the morphinan ...
Weijiao Huang +17 more
semanticscholar +1 more source
Biased signaling by endogenous opioid peptides
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance There are >20 different endogenous opioid peptides derived from the three precursors proopiomelanocortin, proenkephalin, and prodynorphin; a long-standing question is the biological utility of having this variety of peptides.
I. Gomes +7 more
semanticscholar +1 more source
Identifying Risk of Opioid Use Disorder for Patients Taking Opioid Medications with Deep Learning [PDF]
arXiv, 2020 The United States is experiencing an opioid epidemic, and there were more than 10 million opioid misusers aged 12 or older each year. Identifying patients at high risk of Opioid Use Disorder (OUD) can help to make early clinical interventions to reduce the risk of OUD.
arxiv
Nucleus Accumbens μ-Opioid Receptors Mediate Social Reward
Journal of Neuroscience, 2011 Positive social interactions are essential for emotional well-being and proper behavioral development of young individuals. Here, we studied the neural underpinnings of social reward by investigating the involvement of opioid neurotransmission in the ...
V. Trezza +3 more
semanticscholar +1 more source