Results 101 to 110 of about 512,940 (405)

The dark side of opioids in pain management: basic science explains clinical observation

PAIN Reports, 2016
. Introduction:. In the past 2 decades, opioids have been used increasingly for the treatment of persistent pain, and doses have tended to creep up. As basic science elucidates mechanisms of pain and analgesia, the cross talk between central pain and ...
Cyril Rivat, Jane Ballantyne
doaj   +1 more source

In vitro and in vivo pharmacological activities of 14-o-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice [PDF]

, 2018
Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs.
Lattanzi, Roberta, Negri, Lucia, Rief, Silvia, Schmidhammer, Helmut, Spetea, Mariana.   +4 more
core   +2 more sources

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

Incidence and Predictive Factors for Prolonged Use of Opioid Medication After Foot and Ankle Surgery

Foot & Ankle Orthopaedics, 2018
Category: Other Introduction/Purpose: The purpose of this study is to evaluate the incidence and factors predictive for patients’ needs for opioid pain medication longer than 2 weeks after orthopaedic foot/ankle surgery in a single surgeon’s practice at ...
Jamal Ahmad MD
doaj   +1 more source

Status and Rationality of Opioid Use in Lung Cancer Patients: A Single Center Retrospective Study

Chinese Journal of Lung Cancer, 2020
Background and objective Cancer pain affect the physical activity, psychological state and quality of life seriously, and even shortened the survival time of patients.
Wenjuan SUN, Yang HU, Wei ZUO, Bo ZHANG, Yan XU   +4 more
doaj   +1 more source

Reframing the Prevention Strategies of the Opioid Crisis: Focusing on Prescription Opioids, Fentanyl, and Heroin Epidemic.

Pain Physician, 2018
The opioid epidemic has been called the "most consequential preventable public health problem in the United States." Though there is wide recognition of the role of prescription opioids in the epidemic, evidence has shown that heroin and synthetic ...
L. Manchikanti, Jaya Sanapati, Ramsin M. Benyamin, S. Atluri, A. Kaye, J. Hirsch   +5 more
semanticscholar   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]

, 2019
Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben, Atayee, Rabia S, Makunts, Tigran, U, Andrew   +3 more
core   +1 more source

Contributions of prescribed and non-prescribed opioids to opioid related deaths: population based cohort study in Ontario, Canada

British medical journal, 2018
Objective To describe the contributions of prescribed and non-prescribed opioids to opioid related deaths. Design Population based cohort study. Setting Ontario, Canada, from 1 January 2013 to 31 December 2016.
T. Gomes, W. Khuu, Diana Martins, Mina Tadrous, M. Mamdani, J. Paterson, D. Juurlink   +6 more
semanticscholar   +1 more source

“I never realized how hard recovery is.” A quasi‐experimental evaluation of a youth participatory action research project for opioid prevention

American Journal of Community Psychology, EarlyView.
Abstract Youth participatory action research (YPAR) has been effectively used for substance use prevention. Yet, YPAR has not been evaluated for opioids, which negatively impact individuals and communities across the United States. The current study evaluated an opioid‐focused YPAR project.
Elizabeth H. Weybright, Katherine Hampilos, Alison J. White, Cassandra Grinstead, Jennifer Fees, Melanie Greer, Erica L. Doering, Laurie M. Graham   +7 more
wiley   +1 more source