Results 131 to 140 of about 385,486 (311)
Chemistry &Biodiversity, Accepted Article.The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its promising ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Challenges and achievements of peptide synthesis in aqueous and micellar media
ChemBioChem, Accepted Article.Peptides are being increasingly explored for drug development as well as other applications, ranging from research tools to food additives. This growing interest in peptides has led to the need to develop new sustainable synthetic approaches for this class of molecules. The present review article focuses on the synthesis of peptides in aqueous media to
Alessandro Angelini +2 more
wiley +1 more source
Addictive Behaviors Reports, 2022 Background: Opioids and stimulants are the most commonly injected illicit drugs worldwide and in Australia. While some people who inject drugs (PWID) prefer either opioids or stimulants, others regularly use both opioids and stimulants. Limited available
L. Brener +6 more
doaj
Speaking of Stigma: Piloting Language Training in Addiction Counseling Coursework
Counselor Education and Supervision, EarlyView.ABSTRACT This pilot study examined counselor‐in‐training (CIT) attitudes and awareness regarding stigma and stigmatizing language aimed at those with substance use disorders before and after an author‐developed educational intervention. Results indicated this intervention positively impacted CIT awareness and attitudes and their ability to identify and
Amy L. Grybush +2 more
wiley +1 more source
ChemMedChem, EarlyView.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
ChemMedChem, EarlyView.This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino +7 more
wiley +1 more source
ChemMedChem, Accepted Article.The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid +8 more
wiley +1 more source
Health disparities in chronic liver disease
Hepatology, EarlyView., 2022 Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian +3 more
wiley +1 more source
Differential ontogeny of multiple opioid receptors (mu, delta, and kappa) [PDF]
, 1985 J W Spain, BL Roth, CJ Coscia
openalex +1 more source