Results 11 to 20 of about 410,058 (309)

CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022

MMWR Recommendations and Reports, 2022
Summary This guideline provides recommendations for clinicians providing pain care, including those prescribing opioids, for outpatients aged ≥18 years.
D. Dowell, Kathleen R. Ragan, Christopher M. Jones, G. Baldwin, R. Chou   +4 more
semanticscholar   +1 more source

Opioids and Chronic Pain: An Analytic Review of the Clinical Evidence

Frontiers in Pain Research, 2021
We conducted an analytic review of the clinical scientific literature bearing on the use of opioids for treatment of chronic non-cancer pain in the United States.
S. Nadeau, Jeffrey K. Wu, R. Lawhern
semanticscholar   +1 more source

Vital Signs: Characteristics of Drug Overdose Deaths Involving Opioids and Stimulants — 24 States and the District of Columbia, January–June 2019

MMWR. Morbidity and mortality weekly report, 2020
Introduction Provisional estimates indicate that drug overdose deaths increased in 2019 after a slight decrease in 2018. In 2018, overdose deaths primarily involved opioids, with continued increases in deaths involving illicitly manufactured fentanyls ...
J. O'Donnell, R. Gladden, C. Mattson, Calli T. Hunter, N. Davis   +4 more
semanticscholar   +1 more source

Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation

British medical journal, 2020
Objective To examine the associations between stopping treatment with opioids, length of treatment, and death from overdose or suicide in the Veterans Health Administration. Design Observational evaluation.
Elizabeth M Oliva, Thomas R. Bowe, A. Manhapra, S. Kertesz, Jennifer M. Hah, Patricia T Henderson, Amy Robinson, Meenah C Paik, F. Sandbrink, A. Gordon, J. Trafton   +10 more
semanticscholar   +1 more source

The Evolving Overdose Epidemic: Synthetic Opioids and Rising Stimulant-Related Harms.

Epidemiologic Reviews, 2020
The opioid overdose epidemic is typically described as having occurred in 3 waves, with morbidity and mortality accruing over time principally from prescription opioids (1999-2010), heroin (2011-2013), and illicit fentanyl and other synthetic opioids ...
Christopher M Jones, Faraah N Bekheet, Ju Nyeong Park, G. Alexander   +3 more
semanticscholar   +1 more source

Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway

Cell Reports, 2020
Summary: Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction.
Lining Liang, Jinlong Chen, Yuan Li, Xiaowei Lai, Hao Sun, Changpeng Li, Mengdan Zhang, Tingting Yang, Fei Meng, Ping-Yee Law, Horace H. Loh, Hui Zheng   +11 more
doaj   +1 more source

Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis

Journal of the American Medical Association (JAMA), 2018
Importance Harms and benefits of opioids for chronic noncancer pain remain unclear. Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic noncancer pain.
J. Busse, Li Wang, M. Kamaleldin, S. Craigie, J. Riva, Luis Montoya, S. Mulla, L. Lopes, N. Vogel, E. Chen, K. Kirmayr, Kyle De Oliveira, L. Olivieri, Alka Kaushal, L. Chaparro, Inna Oyberman, A. Agarwal, R. Couban, Ludwig Tsoi, T. Lam, P. Vandvik, Sandy Hsu, M. Bała, S. Schandelmaier, A. Scheidecker, S. Ebrahim, Vahid Ashoorion, Y. Rehman, P. Hong, S. Ross, B. Johnston, R. Kunz, Xin Sun, N. Buckley, D. Sessler, G. Guyatt   +35 more
semanticscholar   +1 more source

Causal effects of opioids on postpartum depression: a bidirectional, two-sample Mendelian randomization study

Frontiers in Psychiatry, 2023
BackgroundPostpartum depression is the most common psychiatric disorder in pregnant women during the postpartum period and requires early detection and treatment.
Yage Jiang, Donglei Wei, Yubo Xie, Yubo Xie   +3 more
doaj   +1 more source

Epidemiological trends in opioid-only and opioid/polysubstance-related death rates among American Indian/Alaska Native populations from 1999 to 2019: a retrospective longitudinal ecological study

BMJ Open, 2022
Objectives The rate of drug overdose deaths in the USA has more than tripled since the turn of the century, and rates are disproportionately high among the American Indian/Alaska Native (AI/AN) population.
Fares Qeadan, Erin F Madden, Nana A Mensah, Benjamin Tingey, Jalene Herron, Alexandra Hernandez-Vallant, Kamilla L Venner, Kevin English, Amruta Dixit   +8 more
doaj   +1 more source

An integrative comparative study between ultrasound-guided regional anesthesia versus parenteral opioids alone for analgesia in emergency department patients with hip fractures: A systematic review and meta-analysis

Heliyon, 2022
Background: Emergency physicians play a major role in managing patients with hip fractures. The most commonly used pain management option is parenteral opioids. However, parenteral opioids are subjected to several adverse effects.
Hany A. Zaki, Haris Iftikhar, Nabil Shallik, Amr Elmoheen, Khalid Bashir, Eman E. Shaban, Aftab Mohammad Azad   +6 more
doaj   +1 more source