Results 11 to 20 of about 512,940 (405)

CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022

open access: yesMMWR Recommendations and Reports, 2022
Summary This guideline provides recommendations for clinicians providing pain care, including those prescribing opioids, for outpatients aged ≥18 years.
D. Dowell   +4 more
semanticscholar   +1 more source

Opioids and Chronic Pain: An Analytic Review of the Clinical Evidence

open access: yesFrontiers in Pain Research, 2021
We conducted an analytic review of the clinical scientific literature bearing on the use of opioids for treatment of chronic non-cancer pain in the United States.
S. Nadeau, Jeffrey K. Wu, R. Lawhern
semanticscholar   +1 more source

Vital Signs: Characteristics of Drug Overdose Deaths Involving Opioids and Stimulants — 24 States and the District of Columbia, January–June 2019

open access: yesMMWR. Morbidity and mortality weekly report, 2020
Introduction Provisional estimates indicate that drug overdose deaths increased in 2019 after a slight decrease in 2018. In 2018, overdose deaths primarily involved opioids, with continued increases in deaths involving illicitly manufactured fentanyls ...
J. O'Donnell   +4 more
semanticscholar   +1 more source

Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation

open access: yesBritish medical journal, 2020
Objective To examine the associations between stopping treatment with opioids, length of treatment, and death from overdose or suicide in the Veterans Health Administration. Design Observational evaluation.
Elizabeth M Oliva   +10 more
semanticscholar   +1 more source

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression

open access: yesFrontiers in Physiology, 2021
Pregnant women and developing infants are understudied populations in the opioid crisis, despite the rise in opioid use during pregnancy. Maternal opioid use results in diverse negative outcomes for the fetus/newborn, including death; however, the ...
Austin D. Hocker   +3 more
doaj   +1 more source

Benefits of thoracic epidural analgesia in patients undergoing an open posterior component separation for abdominal herniorrhaphy [PDF]

open access: yes, 2017
INTRODUCTION: The implementation of open posterior component separation (PCS) surgery has led to improved outcomes for complex hernias. While the PCS technique has been shown to decrease recurrence rates, and provide a feasible option to repair hernias ...
Sellers, Austin
core   +1 more source

Trauma and acute care surgeons report prescribing less opioids over time. [PDF]

open access: yes, 2019
IntroductionConfronted with the opioid epidemic, surgeons must play a larger role to reduce risk of opioid abuse while managing acute pain. Having a better understanding of the beliefs and practices of trauma and acute care surgeons regarding discharge ...
Anderson, Jamie E   +2 more
core   +2 more sources

The Evolving Overdose Epidemic: Synthetic Opioids and Rising Stimulant-Related Harms.

open access: yesEpidemiologic Reviews, 2020
The opioid overdose epidemic is typically described as having occurred in 3 waves, with morbidity and mortality accruing over time principally from prescription opioids (1999-2010), heroin (2011-2013), and illicit fentanyl and other synthetic opioids ...
Christopher M Jones   +3 more
semanticscholar   +1 more source

Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway

open access: yesCell Reports, 2020
Summary: Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate downstream signal transduction.
Lining Liang   +11 more
doaj   +1 more source

Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis

open access: yesJournal of the American Medical Association (JAMA), 2018
Importance Harms and benefits of opioids for chronic noncancer pain remain unclear. Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic noncancer pain.
J. Busse   +35 more
semanticscholar   +1 more source

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