Results 21 to 30 of about 226,084 (315)

Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients

Critical Care, 2019
Background In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious.
Candelaria de Haro, Rudys Magrans, Josefina López-Aguilar, Jaume Montanyà, Enrico Lena, Carles Subirà, Sol Fernandez-Gonzalo, Gemma Gomà, Rafael Fernández, Guillermo M. Albaiceta, Yoanna Skrobik, Umberto Lucangelo, Gastón Murias, Ana Ochagavia, Robert M. Kacmarek, Montserrat Rue, Lluís Blanch, for the Asynchronies in the Intensive Care Unit (ASYNICU) Group   +17 more
doaj   +1 more source

Real-world patterns of opioid therapy initiation in Spain, 2012–2018: A population-based, retrospective cohort study with 957,080 patients and 1,509,488 initiations

Frontiers in Pharmacology, 2022
Introduction: Europe has seen a steady increase in the use of prescription opioids, especially in non-cancer indications. Epidemiological data on the patterns of use of opioids is required to optimize prescription.
Isabel Hurtado, Isabel Hurtado, Celia Robles, Celia Robles, Salvador Peiró, Salvador Peiró, Aníbal García-Sempere, Aníbal García-Sempere, Fran Llopis-Cardona, Fran Llopis-Cardona, Francisco Sánchez-Sáez, Francisco Sánchez-Sáez, Clara Rodríguez-Bernal, Clara Rodríguez-Bernal, Gabriel Sanfélix-Gimeno, Gabriel Sanfélix-Gimeno   +15 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

EFFICACY OF PAIN MANAGEMENT AT PREHOSPITAL STAGE IN CHILDREN WITH SEVERE THERMAL TRAUMA

Вестник анестезиологии и реаниматологии, 2018
To describe the frequency and type of EMS analgesic administration to burned children; to describe pain after PICU admission used specific score FLACC and Wong-Baker FACES factors associated with the administration of analgesia by EMS.
D. K. Azovskiy, A. U. Lekmanov, L. I. Budkevich, S. F. Pilutik, D. S. Gudilov   +4 more
doaj   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Unwanted Clinical Complications Following the Consumption of Death Coffee: A Case Series

Neuropsychopharmacology Reports
“Death Coffee” is an incredibly potent brew with caffeine content three times higher than conventional coffees, making it the strongest coffee in the world.
Amir‐Hassan Bordbari, Mahkameh Soltani, Yousef Ashoori, Fatemeh Moslemi Najarcolaii, Zakaria Zakariaei   +4 more
doaj   +1 more source

Single Fascia Iliaca Compartment Block is Safe and Effective for Emergency Pain Relief in Hip-fracture Patients

Western Journal of Emergency Medicine, 2015
Introduction: Currently, it is common practice in the emergency department (ED) for pain relief in hip-fracture patients to administer pain medication, commonly systemic opioids.
Leonieke Groot, Lea M. Dijksman, Maarten P. Simons, Mariska M.S. Zwartsenburg, Jasper R. Rebel   +4 more
doaj   +1 more source

Profile of drug users in the residential treatment centers of Tehran, Iran [PDF]

Health Promotion Perspectives, 2019
Background: The current study aimed at determining the pattern of drug dependence and its related factors in mid-term residential treatment centers (MTRCs). Methods: The current cross-sectional study was conducted on all drug dependent people residing in
Hossein Akbari, Mohsen Roshanpajouh, Keramat Nourijelyani, Mohammad-Ali Mansournia, Afarin Rahimi-Movaghar, Kamran Yazdani   +5 more
doaj   +1 more source

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

The Nature of Opioids Used as Pain Management in A Public Hospital in Bali

Jurnal Ilmiah Medicamento
Opioids are the mainstay of pain management, particularly in chronic pain-related and nonrelated cancer. Studies have shown that the number of opioids used globally varies. It was used excessively in some parts, while in others, it was underused.
Desak Ketut Ernawati, Agata Widatama
doaj   +1 more source