Results 21 to 30 of about 410,058 (309)

Analgesic impact of intra‐operative opioids vs. opioid‐free anaesthesia: a systematic review and meta‐analysis

Anaesthesia, 2019
Opioids are administered peri‐operatively for postoperative analgesia, and intra‐operatively to control the sympathetic response to surgical stimuli, frequently as a surrogate for presumed pain.
J. Frauenknecht, K. Kirkham, A. Jacot-Guillarmod, E. Albrecht   +3 more
semanticscholar   +1 more source

Abuse and Diversion of Immediate Release Opioid Analgesics as Compared to Extended Release Formulations in the United States. [PDF]

PLoS ONE, 2016
Therapeutic use and abuse of prescription opioids in the United States increased substantially between 1990 and 2010. The Centers for Disease Control estimated deaths related to pharmaceutical opioids reached nearly 19,000 in 2014.
Janetta L Iwanicki, S Geoff Severtson, Heather McDaniel, Andrew Rosenblum, Chunki Fong, Theodore J Cicero, Matthew S Ellis, Steven P Kurtz, Mance E Buttram, Richard C Dart   +9 more
doaj   +1 more source

Endogenous and Exogenous Opioids in Pain.

Annual Review of Neuroscience, 2018
Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse and overdose.
G. Corder, Daniel C. Castro, M. Bruchas, G. Scherrer   +3 more
semanticscholar   +1 more source

Quantifying unused opioids following emergency and ambulatory care: A systematic review and meta‐analysis

Journal of the American College of Emergency Physicians Open, 2022
Objective To quantify unused opioids among adult and pediatric patients discharged from the emergency department (ED) or ambulatory care settings with a prescription for acute pain.
Michele P. Dyson, Kathryn Dong, William Sevcik, Samir Z. Graham, Sabrina Saba, Lisa Hartling, Samina Ali   +6 more
doaj   +1 more source

Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis

British medical journal, 2017
Objectives To identify trends in concurrent use of a benzodiazepine and an opioid and to identify the impact of these trends on admissions to hospital and emergency room visits for opioid overdose.
E. Sun, A. Dixit, K. Humphreys, B. Darnall, L. Baker, S. Mackey   +5 more
semanticscholar   +1 more source

Examining prevalence and correlates of smoking opioids in British Columbia: opioids are more often smoked than injected

Substance Abuse Treatment, Prevention, and Policy, 2021
Background British Columbia (BC) is in the midst of an opioid overdose crisis. Since 2017, smoking illicit drugs has been the leading mode of drug administration causing overdose death.
Stephanie Parent, Kristi Papamihali, Brittany Graham, Jane A. Buxton   +3 more
doaj   +1 more source

Pilot findings on the real-world performance of xylazine test strips for drug residue testing and the importance of secondary testing methods

Drug and Alcohol Dependence Reports
Background: Xylazine is a sedative found increasingly in the illicit fentanyl supply that can cause hypotension, bradycardia, necrosis and death. This pilot examined the real-world performance of BTNX xylazine test strips (XTS) in drug residue samples ...
Erin Thompson, Jessica Tardif, Merci Ujeneza, Adina Badea, Traci C. Green, Haley McKee, Michelle McKenzie, Ju Nyeong Park   +7 more
doaj   +1 more source

A Nationwide Hospital Claims Database Analysis of Real-World Patterns of Laxative Use for Opioid-Induced Constipation in Japanese Patients with Cancer

Pain and Therapy, 2023
Introduction Opioid-induced constipation (OIC) is one of the most common side effects in patients with cancer treated with opioid analgesics. The actual use of laxatives for OIC in Japan remains unelucidated.
Takahiro Higashibata, Takaomi Kessoku, Yasuhide Morioka, Yuichi Koretaka, Hirokazu Mishima, Hidetoshi Shibahara, Yuriko Masuda, Yasushi Ichikawa, Atsushi Nakajima, Takayuki Hisanaga   +9 more
doaj   +1 more source

Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients

Critical Care, 2019
Background In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious.
Candelaria de Haro, Rudys Magrans, Josefina López-Aguilar, Jaume Montanyà, Enrico Lena, Carles Subirà, Sol Fernandez-Gonzalo, Gemma Gomà, Rafael Fernández, Guillermo M. Albaiceta, Yoanna Skrobik, Umberto Lucangelo, Gastón Murias, Ana Ochagavia, Robert M. Kacmarek, Montserrat Rue, Lluís Blanch, for the Asynchronies in the Intensive Care Unit (ASYNICU) Group   +17 more
doaj   +1 more source

Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study

PLoS Medicine, 2017
Background Prescription opioid use is highly associated with risk of opioid-related death, with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first opioid prescription.
T. Gomes, D. Juurlink, T. Antoniou, M. Mamdani, J. Paterson, W. van den Brink   +5 more
semanticscholar   +1 more source