Results 91 to 100 of about 4,457,338 (303)

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Serum Metabolome and Lipidome Changes in Adult Patients with Primary Dengue Infection [PDF]

, 2013
10.1371/journal.pntd.0002373PLoS Neglected Tropical ...
A Mangerich, A Mathew, A Sreekumar, A Zuniga, AL St John, B Brugger, BR Murphy, C Lu, C Rothwell, CF Nathan, Choon Nam Ong, CN Serhan, CN Serhan, DJ Gubler, DJ Gubler, DL Diamond, DP Ng, E Avota, E Sandalova, E Zaitseva, E Zigmond, EC Laiakis, EG Bligh, EL Azeredo, Eng Eong Ooi, F Facciotti, Fengguo Xu, G Birungi, G Hasko, GF Nixon, J Chen, J Guarner, J Herz, J Mattner, J Xia, JC Suvarna, JG Low, JG Low, JH Yang, JK Nicholson, K Izawa, K Jessie, K Myo, Kun Lu, L Gil, Liang Cui, MC Ruzek, ME Miller, MG Guzman, N Vinayavekhin, NS Heaton, P Klassen, PC Calder, PC Neves-Souza, PG Hellewell, PJ Brennan, R Al-Mubarak, R Takhampunya, RA Lewis, RC Seet, RL Shaner, RW Wannemacher Jr, S Noisakran, SB Halstead, Scott F. Michael, SJ Gagnon, SL Tilley, Steven R. Tannenbaum, T Akaike, T Kawano, T Pluskal, TJ Nevalainen, W Shi, WW Goh, X Han, Y Kumar, YA Hannun, Yadunanda Kumar, Yie Hou Lee, Z Wang   +79 more
core   +4 more sources

A Short Review Based on the Article Entitled “Establishment of Male and Female Eucommia Fingerprints by UPLC Combined with OPLS-DA Model and Its Application”

Journal of Alternative, Complementary & Integrative Medicine, 2023
This also demonstrates that this quantitative method for the identification of male and female E. ulmoides can provide a reference for quality control and chemical composition studies of male and female E ...
Luping Qin, Xiongyu Meng
openaire   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Comprehensive flavor characterization and fingerprint construction of fermented pepper

Food Chemistry: X
Fermented pepper exhibits complex and diverse flavor profiles, yet traditional fermentation often leads to unstable flavor quality. In this study, electronic nose (E-nose), electronic tongue (E-tongue), high performance liquid chromatography (HPLC) and ...
Yuan Liu, Peiquan Yang, Biqing He, Li Zhu, Fangming Deng, Lingyan Zhao   +5 more
doaj   +1 more source

Nanoflow-nanospray mass spectrometry metabolomics reveals disruption of the urinary metabolite profiles of HIV-positive patients on combination antiretroviral therapy [PDF]

, 2017
Background: The use of combination antiretroviral therapy (cART) has substantially improved the outlook for patients with HIV infection. However, lifelong exposure to cART is also associated with adverse metabolic changes and an enhanced risk of renal ...
Abdul-Sada, Alaa, Bremner, Stephen A, Chetwynd, Andrew J, Gilleece, Yvonne, Hill, Elizabeth M, Holt, Stephen G, Samarawickrama, Amanda, Vera, Jaime H   +7 more
core   +1 more source

Untargeted metabolomics to reveal red versus white meat‐associated gut metabolites in a prudent and western dietary context [PDF]

, 2020
Scope: To improve understanding of the epidemiological link between red and processed meat consumption and chronic diseases, more insight in the formation of metabolites during meat digestion is warranted.Methods and results: Untargeted MS ...
De Smet, Stefaan, Goethals, Sophie, Hemeryck, Lieselot, Rombouts, Caroline, Van Camp, John, Van Hecke, Thomas, Van Meulebroek, Lieven, Vanhaecke, Lynn, Vossen, Els   +8 more
core   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Effects of Lactobacillus plantarum on Physicochemical Properties and Volatile Flavor Substances of Blueberry Juice during Fermentation and Storage

Shipin gongye ke-ji
In order to understand the effects of Lactobacillus plantarum on physicochemical properties and volatile flavor substances of blueberry juice during fermentation and storage stages.
Maowen LIAO, Chen HAN, Wei LIU, Yanlin LI, Changlin CHEN, Huaiyu YUAN, Yan ZHOU, Ke LI, Huajia LI   +8 more
doaj   +1 more source