Results 21 to 30 of about 421 (134)

Machine Learning-Enhanced Model-Based Optical Proximity Correction by Using Convolutional Neural Network-Based Variable Threshold Method

IEEE Access
As the lithography process continues to become more rigorous in advanced technology nodes, the model-based optical proximity correction (MBOPC), as a core component within computational lithography, necessitates the development of highly precise ...
Jinhao Zhu, Zhiwei Ren, Ying Li, Xianhe Liu, Qiang Wu, Yanli Li, Qi Wang   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, Volume 20, Issue 10, Page 2393-2409, October 2026.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Digital Twins for Offshore Wind Operation and Maintenance: A Review

Wind Energy, Volume 29, Issue 10, October 2026.
ABSTRACT Offshore wind has become a key focus for achieving carbon neutrality. However, offshore wind turbines face considerable operational and maintenance challenges due to harsh conditions and difficult access. Integrating digital twin technology helps support operation and maintenance activities.
Xiaomei Hu, Ravi Pandit, Yifan Zhao, Bernadin Namoano, Jiarong Hong   +4 more
wiley   +1 more source

Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD), but its contribution to disease pathogenesis remains incompletely understood. METHODS Here, we integrate proteomic profiling of plasma (n = 9028), cerebrospinal fluid (n = 1099), dorsolateral prefrontal cortex (n = 720), and ...
Artur Shvetcov, Shannon Thomson, Mark E. Graham, Brittany Hauger, Jessica E. Keller, Christine J. Smoyer, Sarah E. Tague, Ann‐Na Cho, Farhad B. Imam, Varsha Krish, Global Neurodegeneration Proteomics Consortium (GNPC), Matthew K. Taylor, Jonathan D. Mahnken, Debra K. Sullivan, Joanne H. Reed, Jeffrey M. Burns, Chad Slawson, Russell H. Swerdlow, Heather M. Wilkins, Caitlin A. Finney   +19 more
wiley   +1 more source

PolygonTailor: A Parallel Algorithm for Polygon Boolean Operations in IC Layout Processing

Algorithms
Polygon Boolean operations are widely used in integrated circuit (IC) layout processing tasks such as design rule checking (DRC) and optical proximity correction (OPC).
Zhirui Niu, Ruian Ji, Guan Wang, Siao Guo, Shijie Ye, Lan Chen   +5 more
doaj   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, Volume 13, Issue 48, 28 August 2026.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

Metal Halide Perovskite Quantum Dots for Luminescence Sensing and Imaging

Nano Select, Volume 7, Issue 8, August 2026.
This review highlights recent advances in metal halide perovskite quantum dots (PQDs)‐based photoluminescence, chemiluminescence, and electroluminescence sensing methods, as well as bioimaging applications. Key challenges, potential solutions, and future opportunities are discussed to guide the development of robust PQD‐based sensing platforms ...
Tooba Hallaj, Rana Salari, Seyyed Morteza Seyyed Alavi, Muhammad Munir, Niko Hildebrandt, Mohammad Amjadi   +5 more
wiley   +1 more source

Machine Learning-Enhanced Model-Based Optical Proximity Correction Framework With Convolutional Neural Network-Based Variable Threshold Method Near the Diffraction Limit

IEEE Access
As semiconductor manufacturing approaches the diffraction limit of lithography, traditional model-based optical proximity correction (MBOPC) techniques face accuracy bottlenecks due to physical modeling errors. This study proposes a Machine Learning (ML)-
Jinhao Zhu, Liwan Yue, Ying Li, Xianhe Liu, Qiang Wu, Qi Wang, Yanli Li   +6 more
doaj   +1 more source