Results 31 to 40 of about 55,224 (387)
Cell, 2010 Optogenetic methods use light to modulate the activities of target cells in vivo. By improving inter- and intracellular trafficking of light-sensitive switch proteins called opsins, Gradinaru et al. (2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency.
Liu, Xu, Tonegawa, Susumu
openaire +4 more sources
Optogenetics: Solving the Enigma of Sleep [PDF]
Sleep Medicine Research, 2018 Sleep is a crucial and evolutionarily conserved phenomenon, but the mechanisms that control sleep-wake behavior and underlie sleep disorders are not yet fully understood.
Victor James Drew, Jae Meen Lee, Tae Kim
doaj +1 more source
Frontiers in Psychiatry, 2022 BackgroundsThe neural circuit mechanisms underlying depression remain unclear. Recently optogenetics has gradually gained recognition as a novel technique to regulate the activity of neurons with light stimulation.
Shanshan Lin +11 more
doaj +1 more source
Tools for Controlling Activity of Neural Circuits Can Boost Gastrointestinal Research [PDF]
, 2016 We thank Prof U. G. Knaus and T. C. Collin for critical reading of the manuscript. GA is supported by the European Crohn's and Colitis Organization (ECCO) (J/15/2) and by the National Childrens' Research Centre (K/12/1). GD is supported by the University
Aviello, Gabriella, D'Agostino, Giuseppe
core +6 more sources
Closed-loop targeted optogenetic stimulation of C. elegans populations [PDF]
PLoS Biol 20(1): e3001524, 2021, 2021 We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three technical challenges: it delivers targeted illumination to specified regions of the animal's body such as its head or tail; it automatically ...
arxiv +1 more source
Optogenetics Illuminates Applications in Microbial Engineering.
Annual Review of Chemical and Biomolecular Engineering, 2022 Optogenetics has been used in a variety of microbial engineering applications, such as chemical and protein production, studies of cell physiology, and engineered microbe-host interactions.
Shannon M. Hoffman +2 more
semanticscholar +1 more source
Probing subthreshold dynamics of hippocampal neurons by pulsed optogenetics
Science, 2022 Understanding how excitatory (E) and inhibitory (I) inputs are integrated by neurons requires monitoring their subthreshold behavior. We probed the subthreshold dynamics using optogenetic depolarizing pulses in hippocampal neuronal assemblies in freely ...
Manuel Valero +3 more
semanticscholar +1 more source
Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans [PDF]
, 2012 The C. elegans nervous system is particularly well suited for optogenetic analyses of circuit function: Essentially all connections have been mapped, and light can be directed at the neuron of interest in the freely moving, transparent animals, while ...
Erbguth, Karen +4 more
core +5 more sources
Emerging optogenetics technologies in biomedical applications
Smart Medicine, 2023 Optogenetics is a cutting‐edge technology that merges light control and genetics to achieve targeted control of tissue cells. Compared to traditional methods, optogenetics offers several advantages in terms of time and space precision, accuracy, and ...
Haozhen Ren +4 more
doaj +1 more source
Optogenetics in primate cortical networks
Frontiers in Neuroanatomy, 2023 The implementation of optogenetics in studies on non-human primates has generally proven quite difficult, but recent successes have paved the way for its rapid increase.
Sam Merlin +2 more
doaj +1 more source