Results 171 to 180 of about 3,353,625 (210)

Specialized cortical ER architecture modulates Ca²⁺ signaling dynamics. [PDF]

iScience
Courjaret RJ, Lee L, Mohamed H, Yu F, Assaf L, Fisher M, Yule DI, Terasaki M, Sneyd J, Machaca K.   +9 more
europepmc   +1 more source

Immune sentinel function of nasal mucosal epithelial cells in allergic rhinitis: a review on barrier damage and inflammatory amplification loops regulated by calcium signalling. [PDF]

Front Immunol
Liu Y, Sun Q, Meng C, Sha J, Zhu D, Wu N.   +5 more
europepmc   +1 more source

<i>ORAI1</i> mutation with mixed loss and gain of function properties causes immunodeficiency and HLH. [PDF]

J Hum Immun
Noyer L, Yeung PS, Kahlfuss S, Li Lai C, McDermott M, Patel D, Yang J, Wang YH, Zhong L, Hsu P, Prakriya M, Feske S.   +11 more
europepmc   +1 more source

Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction. [PDF]

JCI Insight
Willer AS, Ruffenach G, Masson B, El Jekmek K, Boët A, Adão R, Gourmelon M, Beauvais A, Sabourin J, Dutheil M, Ghigna MR, Tesson L, Ménoret S, Anegon I, Bauer F, de Montpréville V, Hebbar S, Brás-Silva C, Stauderman K, Humbert M, Mercier O, Montani D, Capuano V, Antigny F.   +23 more
europepmc   +1 more source

Quantitative Mapping of the Lipid Nanoenvironment around Transmembrane Proteins in Living Cells. [PDF]

ACS Nano
Brumovska V, Bishara M, Arnold AM, Kalouskova B, Fülöp G, Fahrner M, Derler I, Maltan L, Matsumori N, Brameshuber M, Schütz GJ, Sevcsik E.   +11 more
europepmc   +1 more source

Guardians of T-Cell Ca²⁺ Stores: SERCA Pumps Integrated Within Complex Functional and Disease-State Signaling Dynamics. [PDF]

Cells
Uddin MDN, Thomas DW.
europepmc   +1 more source

A supramolecular complex of palmitoylated Orai C-terminal peptide and cyclodextrin targets the plasma membrane to reduce store-operated calcium channel activity.

Mater Adv
Toledo-Marcos J, Di Geronimo B, Curcic S, Farkas V, Sánchez-Murcia PA, Schindl R, Bacsa B, Horváti K.   +7 more
europepmc   +1 more source

Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation

American Journal of Physiology - Cell Physiology
FLNA cleaving by calpain has been observed in a variety of tumoral, including prostate and colorectal cancer cells, as well as in nontumoral cells, leading to a C-terminal fragment encompassing repeats 16–24. Expression of the FLNA 16–24 fragment in HEK-293 cells enhances Orai1 and STIM1 ...
Pedro J Camello, Joel Nieto Felipe, Tarik Smani   +2 more
exaly   +7 more sources

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension

Circulation Research, 2022
Background: Pulmonary arterial hypertension (PAH) is characterized by progressive distal pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure.
Ma Bailey, Vincent Thomas de Montpreville, Jessica Sabourin   +2 more
exaly   +2 more sources