Results 181 to 190 of about 3,353,625 (210)

PIP2 and septin control STIM1/Orai1 assembly by regulating cytoskeletal remodeling via a CDC42-WASP/WAVE-ARP2/3 protein complex

Cell Calcium, 2021
Store-operated calcium entry (SOCE) is triggered by assembly of Orai1 with STIM proteins in ER-PM junctions. Plasma membrane PIP2 as well as PIP2-binding protein, SEPT4, significantly impact Orai1-STIM1 interaction. While septins and PIP2 can organize the actin cytoskeleton, it is unclear whether the status of actin within the junctions contributes to ...
Lorena Brito de Souza, Indu Ambudkar, Xibao Liu   +2 more
exaly   +3 more sources

Effects of stromal interaction molecule 1 or Orai1 overexpression on the associated proteins and permeability of podocytes

Nephrology, 2016
AbstractAimThe present study was conducted to determine whether two important signalling molecules of store‐operated channel (SOC), stromal interaction molecule 1 (STIM1) and Orai1, were involved in glomerular podocyte injury. We explored the effects of STIM1/Orai1 overexpression on podocyte associated proteins and cell permeability.MethodsThe ...
Li, Miao, Dongyue, Wei, Yuanyuan, Zhang, Jiansheng, Liu, Siguang, Lu, Aihua, Zhang, Songming, Huang   +6 more
openaire   +2 more sources

Identification Of Proteins Involved In Orai1 Trafficking By Mass Spectrometry-based Approach

Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1, 2014
Store-operated calcium entry (SOCE) is a ubiquitous Ca2+ influx pathway essential for many physiological functions. Dysregulation of SOCE causes disruption in Ca2+ homeostasis leading to cellular pathology of several diseases. Orai1, a key regulator of SOCE, constitutively recycles at steady state in the frog oocyte and internalizes into an ...
Maya Dib, Rawad Hodeify, Khaled Machaca
openaire   +1 more source

Differential Roles of the C and N Termini of Orai1 Protein in Interacting with Stromal Interaction Molecule 1 (STIM1) for Ca2+ Release-activated Ca2+ (CRAC) Channel Activation [PDF]

Journal of Biological Chemistry, 2013
The entry of extracellular Ca(2+), which is mediated by Ca(2+) release-activated Ca(2+) (CRAC) channels, is essential for T cell activation and the normal functioning of other immune cells. Although the molecular components of CRAC channels, the Orai1 pore-forming subunit and the STIM1-activating subunit have been recently identified, the gating ...
Xu Peng, Lih Kuo, Changlong Hu
exaly   +3 more sources

Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating [PDF]

Cell Research, 2015
Calcium flux through store-operated calcium entry is a major regulator of intracellular calcium homeostasis and various calcium signaling pathways. Two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing ...
Raz Palty, Ehud Y Isacoff, Cherise Stanley   +2 more
exaly   +2 more sources

Visualizing Quantum Dot Labeled ORAI1 Proteins in Intact Cells Via Correlative Light and Electron Microscopy

Microscopy and Microanalysis, 2016
AbstractORAI1 proteins are ion channel subunits and the essential pore-forming units of the calcium release-activated calcium channel complex essential for T-cell activation and many other cellular processes. In this study, we used environmental scanning electron microscopy (ESEM) with scanning transmission electron microscopy (STEM) detection to image
Diana B, Peckys, Dalia, Alansary, Barbara A, Niemeyer, Niels, de Jonge   +3 more
openaire   +2 more sources

The TRPC Ion Channels: Association with Orai1 and STIM1 Proteins and Participation in Capacitative and Non-capacitative Calcium Entry

2010
Transient receptor potential (TRP) proteins are involved in a large number of non-selective cation channels that are permeable to both monovalent and divalent cations. Two general classes of receptor-mediated Ca(2+) entry has been proposed: one of then is conduced by receptor-operated Ca(2+) channels (ROC), the second is mediated by channels activated ...
Gines M, Salido, Isaac, Jardín, Juan A, Rosado   +2 more
openaire   +2 more sources

Novel mutations in CRAC channel protein Orai1 cause immunodeficiency associated with non-immunological disease (89.23)

The Journal of Immunology, 2007
Abstract Orai1 has recently been identified as a pore subunit of the Ca2+ release activated Ca2+ (CRAC) channel essential for the function of T lymphocytes, mast cells and other cells types. A point mutation in Orai1 abrogates CRAC channel function and causes Severe Combined Immunodeficiency (SCID) in human infants.
Stefan Feske, Ute Osmers, Janbernd Kirschner, Jens Roether, Capucine Picard, Stephan Ehl, Katrin Plogmann, Alain Fischer, Anjana Rao   +8 more
openaire   +1 more source

Orai1 protein expression and the role of calcium release‐activated calcium channels in the contraction of human term‐pregnant and non‐pregnant myometrium

Journal of Obstetrics and Gynaecology Research, 2014
AbstractAimThis experimental in vitro study examined differences in the expression and activity of calcium release‐activated calcium (CRAC) channels of human term‐pregnant and non‐pregnant myometrium.Material and MethodsThe tissue samples were obtained from term‐pregnant myometrium in labor of women undergoing cesarean section and from non‐pregnant ...
Martina, Sutovska, Michaela, Kocmalova, Vladimira, Sadlonova, Karol, Dokus, Marian, Adamkov, Jan, Luptak, Sona, Franova   +6 more
openaire   +2 more sources

SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos

Zygote, 2016
SummaryIn zebrafish embryos, distinct Ca2+transients are localized to the early cleavage furrows during the first few cell division cycles. These transients are generated mainly by release via IP3Rs in the endoplasmic reticulum, and they are necessary for furrow positioning, propagation, deepening and apposition.
Chan, Chingman, Jacqueline theeng mei, Webb, Sarah E., Miller, Andrew L.   +3 more
openaire   +3 more sources