Results 51 to 60 of about 393,980 (293)

Spike-Timing of Orbitofrontal Neurons Is Synchronized With Breathing

Frontiers in Cellular Neuroscience, 2018
The orbitofrontal cortex (OFC) has been implicated in a multiplicity of complex brain functions, including representations of expected outcome properties, post-decision confidence, momentary food-reward values, complex flavors and odors.
Áron Kőszeghy, Bálint Lasztóczi, Thomas Forro, Thomas Klausberger   +3 more
doaj   +1 more source

16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability

Communications Biology, 2023
Autism spectrum disorders are more common in males, and have a substantial genetic component. Chromosomal 16p11.2 deletions in particular carry strong genetic risk for autism, yet their neurobiological impact is poorly characterised, particularly at the ...
Rebecca L. Openshaw, David M. Thomson, Greg C. Bristow, Emma J. Mitchell, Judith A. Pratt, Brian J. Morris, Neil Dawson   +6 more
doaj   +1 more source

A common neural scale for the subjective pleasantness of different primary rewards. [PDF]

, 2010
When an economic decision is taken, it is between goals with different values, and the values must be on the same scale. Here, we used functional MRI to search for a brain region that represents the subjective pleasantness of two different rewards on the
Grabenhorst, F, Passingham, R., D'Souza, AA, De Souza, Arun, Parris, Benjamin, Rolls, ET, Passingham, RE, Rolls, Edmund T., Parris, BA, Passingham, Richard, Grabenhorst, Fabian   +10 more
core   +1 more source

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice

Molecular Autism, 2019
Background Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and recent genetic and mouse evidence ...
Eleftheria Pervolaraki, Adam L. Tyson, Francesca Pibiri, Steven L. Poulter, Amy C. Reichelt, R. John Rodgers, Steven J. Clapcote, Colin Lever, Laura C. Andreae, James Dachtler   +9 more
doaj   +1 more source

Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study

Medicina, 2021
Loss of sense of smell is a well-known non-motor symptom of Parkinson’s disease (PD). Here, we present insight into the association between PD advancement and equivalents of smell loss in olfactory-eloquent brain areas, such as the posterior cortex and ...
Thomas Hummel, Antje Haehner, Divesh Thaploo, Charalampos Georgiopoulos, Björn Falkenburger, Katherine Whitcroft   +5 more
doaj   +1 more source

Volumetric alterations of the orbitofrontal cortex in autism [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2007
Recent evidence has implicated the orbitofrontal cortex (OFC) in the pathophysiology of social deficits in autism. An MRI-based morphometric study of the OFC was conducted involving 11 children with autism (age range 8.1-12.7 years) and 18 healthy, age-matched controls (age range 8.9-12.8 years). Decreased grey matter volume in the right lateral OFC in
Ragy R, Girgis, Nancy J, Minshew, Nadine M, Melhem, Jeffrey J, Nutche, Matcheri S, Keshavan, Antonio Y, Hardan   +5 more
openaire   +2 more sources

The orbitofrontal cortex, food reward, body weight and obesity [PDF]

, 2023
In primates including humans, the orbitofrontal cortex is the key brain region representing the reward value and subjective pleasantness of the sight, smell, taste and texture of food.
Rolls, Edmund T.
core   +1 more source

Brain structure and symptom dimensions in borderline personality disorder

European Psychiatry, 2020
Background.Borderline personality disorder (BPD) presents with symptoms across different domains, whose neurobiology is poorly understood.Methods.We applied voxel-based morphometry on high-resolution magnetic resonance imaging scans of 19 female BPD ...
Igor Nenadić, Annika Voss, Bianca Besteher, Kerstin Langbein, Christian Gaser   +4 more
doaj   +1 more source

Neural correlates of processing valence and arousal in affective words [PDF]

, 2006
Psychological frameworks conceptualize emotion along 2 dimensions, "valence" and "arousal." Arousal invokes a single axis of intensity increasing from neutral to maximally arousing.
P Rotshtein, Lewis, Penelope A., Rotshtein, P., Dolan, RJ, R. Dolan, Dolan, R. ; https://orcid.org/, Rothstein, P., P. A. Lewis, Dolan, R. J., Lewis, P. A., Lewis, PA, Critchley, H.D., Dolan, R.J., Rotshtein, Pia, R. J. Dolan, P. Lewis, Lewis, P.A., Critchley, HD, P. Rotshtein, H. Critchley, Critchley, H. D., Lewis, P., H. D. Critchley, Critchley, H.   +23 more
core   +1 more source

Neuroscience: Reevaluating the Role of Orbitofrontal Cortex [PDF]

Current Biology, 2019
A new optogenetic lesion study shows that the orbitofrontal cortex is essential for integrating information about recent rewards - which may either increase or decrease demand for more - with learned preferences to drive behavior.
Brianna J, Sleezer, Benjamin Yost, Hayden   +1 more
openaire   +2 more sources