Results 51 to 60 of about 17,610 (263)

Orexin-A Hyperphagia: Hindbrain Participation in Consummatory Feeding Responses [PDF]

Endocrinology, 2008
Orexin-A (ORXA) is an orexigenic neuropeptide produced by the lateral hypothalamus that increases food intake when injected into the brain ventricles or forebrain nuclei. We used a licking microstructure analysis to evaluate hindbrain and forebrain ORXA effects in intact and hindbrain-lesioned rats, to identify the motivational and anatomical bases of ...
Baird, J., Choe, A., Loveland, J., Beck, J., Mahoney, C., Lord, J., Grigg, L.   +6 more
openaire   +3 more sources

Behavioral aspects in children's brothers affected by Autism Spectrum Disorders [PDF]

, 2018
Introduction: Autistic Spectrum Disorder (ASD) is a permanent and complex disability arising within the first three years of life characterized by a socio-communicative disorder and by fixed interests and repetitive behaviors.
ANGELO MONTANA, ANNA NUNZIA POLITO, ANNABELLA DI FOLC, BEATRICE GALLAI, DANIELA RUSSO, DAVIDE TEST, DIEGO GERACI, ELISABETTA PICCIOCCHI, FRANCESCO CERRONI, FRANCESCO LAVANO, GABRIELE TRIPI, GABRIELLA MARSALA, LUCIA PARISI, LUCREZIA D’ORO, MARGHERITA SALERNO, MARIA RUBERT, MARIO GIUSEPPE CHISARI, MICHELE SORRENTINO, PALMIRA ROMANO, PAOLO MURABITO, ROSA MAROTTA, ROSARIA MARTINA MAGLIULO, SABRINA FRANCO, SERENA MARIANNA LAVANO   +23 more
core   +1 more source

Interactions between Lateral Hypothalamic Orexin and Dorsal Raphe Circuitry in Energy Balance

Brain Sciences
Orexin/hypocretin terminals innervate the dorsal raphe nucleus (DRN), which projects to motor control areas important for spontaneous physical activity (SPA) and energy expenditure (EE).
Vijayakumar Mavanji, Brianna L. Pomonis, Laurie Shekels, Catherine M. Kotz   +3 more
doaj   +1 more source

Central orexin-A increases gastric motility in rats

Peptides, 2010
Orexin receptor type-1 (OX1R) is expressed in the dorsal motor nucleus of vagi (DMV). Although orexin-A (OXA) plays an important role in mediating stress responses, it remains unclear how central OXA regulates gastric dysmotility induced by stress. Acute restraint stress (ARS) delays solid gastric emptying via the central corticotropin releasing factor
Bulbul, Mehmet, Babygirija, Reji, Ludwig, Kirk, Takahashi, Toku   +3 more
openaire   +3 more sources

Hypothalamus-Olfactory System Crosstalk: Orexin A Immunostaining in Mice [PDF]

Frontiers in Neuroanatomy, 2012
It is well known that olfaction influences food intake, and conversely, that an individual's nutritional status modulates olfactory sensitivity. However, what is still poorly understood is the neuronal correlate of this relationship, as well as the connections between the olfactory bulb and the hypothalamus.
Gascuel, Jean, Lemoine, Aleth, Rigault, Caroline, Datiche, Frédérique, Benani, Alexandre, Pénicaud, Luc, Lopez-Mascaraque, Laura   +6 more
openaire   +6 more sources

DEC2 modulates orexin expression and regulates sleep. [PDF]

, 2018
Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait.
Fu, Ying-Hui, Hirano, Arisa, Hsu, Pei-Ken, McMahon, Thomas, Ptáček, Louis J, Xing, Lijuan, Yamazaki, Maya, Zhang, Luoying   +7 more
core   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, EarlyView.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptors and shows orexin receptor-independent cytotoxicity [PDF]

, 2017
Two promising lead structures of small molecular orexin receptor agonist have been reported, but without detailed analyses of the pharmacological properties.
af Gennas, Gustav Boije, Kukkonen, Jyrki P., Lindholm, Dan, Rinne, Maiju K., Turku, Ainoleena, Xhaard, Henri   +5 more
core   +2 more sources

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Eating and feeding disorders in pediatric age [PDF]

, 2018
Eating and feeding disorders are common in pediatric age and may be important to discover and recover the early symptoms in order to optimize the treatment and ...
Cerroni F., Chisari M. G., D'Oro L., Di Folco A., Franco S., Gallai B., Geraci D., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Murabito P., Parisi L., Picciocchi E., Polito A. N., Romano P., Russo D., Salerno M., Sorrentino M., Testa D., Tripi G.   +20 more
core   +1 more source