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Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems. [PDF]
Front PharmacolZhang S +6 more
europepmc +1 more source
Orexin and Lifestyle Habits: A Meaningful Connection Among Nutrition, Physical Activity, and Sleep Pattern in Health and Diseases. [PDF]
Int J Mol SciNigro E +3 more
europepmc +1 more source
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[Orexins and orexin receptors].
Ceskoslovenska fysiologie, 1999The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. Two novel neuropeptides Orexin -A and -B were identified. Orexins activate two closely related G protein-coupled receptors and stimulate food consumption. They act also as mediators in the central feedback mechanism and regulates feeding behavior.
K, Kotaska, R, Průsa
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2005
“Reverse pharmacological” approaches, i.e., ligand identification using cell lines expressing orphan receptors, combined with genetic engineering techniques, have increased our understanding of novel signaling systems in the body (1). Orexin/hypocretin is the first example of the factors that were successfully applied using such approaches (2).
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“Reverse pharmacological” approaches, i.e., ligand identification using cell lines expressing orphan receptors, combined with genetic engineering techniques, have increased our understanding of novel signaling systems in the body (1). Orexin/hypocretin is the first example of the factors that were successfully applied using such approaches (2).
openaire +1 more source
Journal of Medicinal Chemistry, 2004
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang +4 more
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The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang +4 more
openaire +2 more sources
Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor
Biochemical and Biophysical Research Communications, 2002Orexins (orexin A and B) are recently identified neuropeptides implicated in the regulation of vigilance states and energy homeostasis. We have shown here the physiological significance of histaminergic neurons in the orexin-induced arousal responses. Immunohistochemical and electron microscopic techniques revealed direct synaptic interaction between ...
Akihiro, Yamanaka +9 more
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