Results 211 to 220 of about 29,387 (258)

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Psychopharmacology, 2001
Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine ...
D N, Jones, J, Gartlon, F, Parker, S G, Taylor, C, Routledge, P, Hemmati, R P, Munton, T E, Ashmeade, J P, Hatcher, A, Johns, R A, Porter, J J, Hagan, A J, Hunter, N, Upton   +13 more
openaire   +2 more sources

Orexin Receptor Antagonists

Pharmaceutical Patent Analyst, 2012
The orexin neuropeptides bind to two G protein-coupled receptors, orexin-1 and -2. Small-molecule antagonism of the receptors has potential therapeutic utility in a number of areas, most notably insomnia, for which the most advanced dual orexin receptor antagonist has now completed clinical trials.
openaire   +2 more sources

Glutamate and Orexin Neurons

2012
Orexin neurons are localized in the lateral hypothalamus and regulate many functions including sleep-wake states. Substantial number of neurotransmitters and neuromodulators has been proposed to influence orexinergic system. Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the ...
Minbay, Zehra, EYİGÖR, ÖZHAN, KAFA, İLKER MUSTAFA   +2 more
openaire   +3 more sources

Orexins and orexin receptors: implication in feeding behavior

Regulatory Peptides, 1999
Orexin-A and -B are initially identified as endogenous ligands for an orphan G protein coupled receptor. Since the discovery of orexins, investigations of their functions have been guided by their distribution in the lateral hypothalamic area, which has been implicated in feeding behavior.
openaire   +2 more sources

Orexin Projections and Localization of Orexin Receptors

2006
The past several years have provided important insights into the physiological significance of the central orexin system. An important component of these is an increased understanding of the unique neuroanatomy of the orexin/hypocretin system. The orexin peptides, orexin-A and orexin-B, are produced in a restricted region of the central nervous system,
Jacob N. Marcus, Joel K. Elmquist
openaire   +1 more source

Orexins and Gastrointestinal Functions

Current Protein & Peptide Science, 2010
Orexin A (OXA) and orexin B (OXB) are recently discovered neuropeptides that appear to play a role in various distinct functions such as arousal and the sleep-wake cycle as well as on appetite and regulation of feeding and energy homeostasis. Orexins were first described as neuropeptides expressed by a specific population of neurons in the lateral ...
openaire   +2 more sources

Orexins and Orexin Receptors: From Molecules to Integrative Physiology

2008
Recent studies have implicated the orexin system as a critical regulator of sleep/wake states, feeding behavior, and reward processes. Orexin deficiency results in narcolepsy-cataplexy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Taizo, Matsuki, Takeshi, Sakurai
openaire   +2 more sources

Orexins

2022
Safoor Fathima, Sireesha Murala, Pradeep C. Bollu   +2 more
openaire   +1 more source

Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1

New England Journal of Medicine, 2023
Rafael del Río-Villegas
exaly  

Orexin neurons inhibit sleep to promote arousal

Nature Communications, 2022
Roberto De Luca, Anne Venner, Dong Kong
exaly