Results 211 to 220 of about 20,577 (234)

Effects of orexin receptor antagonism on human sleep architecture: A systematic review

Sleep Medicine Reviews, 2020
Jacob W Clark, Daniel Hoyer, Laura H Jacobson   +2 more
exaly  

[Roles of orexin and effects of orexin receptor antagonists].

Nihon rinsho. Japanese journal of clinical medicine, 2015
Orexin A and orexin B are hypothalamic neuropeptides that were discovered in 1998. Several studies suggested that orexin deficiency causes narcolepsy in humans and other mammalian species, highlighting roles of this hypothalamic neuropeptide in the regulation of sleep and wakefulness.
openaire   +1 more source

The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia

Annual Review of Pharmacology and Toxicology, 2017
Paul J Coleman, Anthony L Gotter, Christopher J Winrow   +2 more
exaly  

Orexin receptor antagonism: an ascending multiple-dose study with almorexant

Journal of Psychopharmacology, 2012
Georg Dorffner, Jasper Dingemanse
exaly  

Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction

FEBS Letters, 2011
Laura Korhonen, Jyrki P Kukkonen, Pauli M Turunen   +2 more
exaly  

Orexin Receptors

2008
openaire   +1 more source

Discovery and Characterization of ACT‐335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

ChemMedChem, 2013
John Gatfield, Alexander Treiber
exaly  

Structure-based development of a subtype-selective orexin 1 receptor antagonist

Proceedings of the National Academy of Sciences of the United States of America, 2020
Jan Hellmann, Matthäus Drabek, Theresa Pröll   +2 more
exaly  

Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders

Expert Opinion on Drug Metabolism and Toxicology, 2020
Clemens Muehlan, Cedric Vaillant, Isabelle Zenklusen   +2 more
exaly  

Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Pharmaceuticals, 2017
Takeshi Sakurai, Innocenzo Rainero, Mary C Maj   +2 more
exaly