Results 201 to 210 of about 20,577 (234)
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Hippocampal orexin receptors: Localization and function
2022Orexin (hypocretin) is secreted from the perifornical/lateral hypothalamus and is well known for sleep regulation. Orexin has two, orexin A and B, transcripts and two receptors, type 1 and 2 (OX1R and OX2R), located in the plasma membrane of neurons in different brain areas, including the hippocampus involved in learning, memory, seizures, and epilepsy,
Mahmoud, Elahdadi Salmani +2 more
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[Orexins and orexin receptors].
Ceskoslovenska fysiologie, 1999The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. Two novel neuropeptides Orexin -A and -B were identified. Orexins activate two closely related G protein-coupled receptors and stimulate food consumption. They act also as mediators in the central feedback mechanism and regulates feeding behavior.
K, Kotaska, R, Průsa
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Role of Orexin-B/Orexin 2 receptor in myocardial protection
Clinical Science, 2019Abstract Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function.
Imperatore Roberta, Cristino Luigia
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Orexin Projections and Localization of Orexin Receptors
2006The past several years have provided important insights into the physiological significance of the central orexin system. An important component of these is an increased understanding of the unique neuroanatomy of the orexin/hypocretin system. The orexin peptides, orexin-A and orexin-B, are produced in a restricted region of the central nervous system,
Jacob N. Marcus, Joel K. Elmquist
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2005
“Reverse pharmacological” approaches, i.e., ligand identification using cell lines expressing orphan receptors, combined with genetic engineering techniques, have increased our understanding of novel signaling systems in the body (1). Orexin/hypocretin is the first example of the factors that were successfully applied using such approaches (2).
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“Reverse pharmacological” approaches, i.e., ligand identification using cell lines expressing orphan receptors, combined with genetic engineering techniques, have increased our understanding of novel signaling systems in the body (1). Orexin/hypocretin is the first example of the factors that were successfully applied using such approaches (2).
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Orexins and Orexin Receptors: From Molecules to Integrative Physiology
2008Recent studies have implicated the orexin system as a critical regulator of sleep/wake states, feeding behavior, and reward processes. Orexin deficiency results in narcolepsy-cataplexy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Taizo, Matsuki, Takeshi, Sakurai
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2016
Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers. One group named it orexin after the Greek word orexis which means “appetite,” while the other group named it hypocretin since it was synthesized in the hypothalamus and resembles ...
Patkar, Omkar L. +2 more
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Orexin or hypocretin; a peptide that resembles the molecular structure of the gastric peptide secretin, was discovered in 1996 by two independent groups of researchers. One group named it orexin after the Greek word orexis which means “appetite,” while the other group named it hypocretin since it was synthesized in the hypothalamus and resembles ...
Patkar, Omkar L. +2 more
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Orexin receptors as therapeutic drug targets
2012Orexin (hypocretin) receptor antagonists stand as a model for the development of targeted CNS small-molecule therapeutics. The identification of mutations in the gene for the orexin 2 receptor responsible for canine narcolepsy, the demonstration of a hypersomnolence phenotype in hypocretin knockout mice and the disruption in orexin signaling in ...
Anthony L, Gotter +5 more
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Bioorganic & Medicinal Chemistry Letters, 2017
In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile ...
Jason W, Skudlarek +20 more
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In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX2R subtype and culminating in the discovery of 23, a highly potent, OX2R-selective molecule that exhibited a promising in vivo profile ...
Jason W, Skudlarek +20 more
openaire +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2022
Haruhide Kimura +2 more
exaly
Haruhide Kimura +2 more
exaly