Results 151 to 160 of about 16,588 (201)

Kainic acid status epilepticus - induced changes in the hippocampus and hypothalamus alter the effects of exogenous Orexin-A in the hippocampus. [PDF]

IBRO Neurosci Rep
Kapanadze T, Bakuradze E, Kutelia G, Chkhartishvili B, Doreulee N.   +4 more
europepmc   +1 more source

Single Nucleotide Polymorphisms in Orexin-1 and BDNF Receptor Genes are Associated with Increased Risk of Developing Postpartum Depression among Women with Gestational Diabetes Mellitus.

Public Health Genomics
Ghazal P, Tariq S, Munshi T.
europepmc   +1 more source

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Orexin Receptor Antagonists and Insomnia

Current Psychiatry Reports, 2022
We review recent evidence on the use of orexin receptor antagonists (ORAs) for treating insomnia. We evaluate studies on five dual ORAs and one selective ORA.Research on suvorexant in recent years gradually focus on comorbid insomnia, while lemborexant and daridorexant were still being validated in primary insomnia.
Xin, Wu, Tao, Xue, Zhouqing, Chen, Zhong, Wang, Gang, Chen   +4 more
openaire   +2 more sources

Orexin receptors: Targets and applications

Fundamental & Clinical Pharmacology, 2021
AbstractOver the years, elucidating targets from the neural circuits that can be used to treat disorders pertaining to the nervous system and extending their scope to other systems have always proved interesting to researchers. The role of various peptides and neurotransmitters has been elucidated and is being developed as therapeutic targets.
Subhiksha Subramanian, Mirunalini Ravichandran   +1 more
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Selective orexin receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2013
The orexin, or hypocretin, neuropeptides (orexin-A and orexin-B) are produced on neurons in the hypothalamus which project to key areas of the brain that control sleep-wake states, modulation of food intake, panic, anxiety, emotion, reward and addictive behaviors.
Terry P, Lebold, Pascal, Bonaventure, Brock T, Shireman   +2 more
openaire   +2 more sources

A molecular network map of orexin-orexin receptor signaling system

Journal of Cell Communication and Signaling, 2022
Orexins are excitatory neuropeptides, which are predominantly associated with feeding behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of HCRTR1 and HCRTR2, G-protein-coupled receptors of rhodopsin family and the endogenous ligands processed from HCRT pro-hormone, Orexin A and Orexin B.
Oishi Chatterjee, Lathika Gopalakrishnan, Deepshika Pullimamidi, Chinmayi Raj, Soujanya Yelamanchi, Bhavya Somaplara Gangadharappa, Bipin Nair, Anita Mahadevan, Rajesh Raju, T. S. Keshava Prasad   +9 more
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Orexin Receptor Antagonists

Pharmaceutical Patent Analyst, 2012
The orexin neuropeptides bind to two G protein-coupled receptors, orexin-1 and -2. Small-molecule antagonism of the receptors has potential therapeutic utility in a number of areas, most notably insomnia, for which the most advanced dual orexin receptor antagonist has now completed clinical trials.
openaire   +2 more sources

Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

Journal of Medicinal Chemistry, 2004
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang, Richard M, Söll, Franz, Dürrenberger, Frank M, Dautzenberg, Annette G, Beck-Sickinger   +4 more
openaire   +2 more sources