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Expression of Orexin Receptors in the Pituitary
2012Orexin receptors type 1 (OX1R) and type 2 (OX2R) are G protein-coupled receptors whose structure is highly conserved in mammals. OX1R is selective for orexin A, and OX2R binds orexin A and orexin B with similar affinity. Orexin receptor expression was observed in human, rat, porcine, sheep as well as Xenopus laevis pituitaries, both in the ...
Tadeusz, Kaminski, Nina, Smolinska
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Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats
Pharmacological Reports, 2019The orexin system regulates various functions, including sleep/wake cycles, feeding, and cognition. Orexin A and orexin B are endogenous neuropeptides for both orexin 1 (OX1) and orexin 2 (OX2) receptors. Orexin A has a potent agonistic activity for both the receptors and is known to increase locomotor activity in rats.
Shunsuke, Maehara +2 more
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Role of Orexin-B/Orexin 2 receptor in myocardial protection
Clinical Science, 2019Abstract Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function.
Imperatore Roberta, Cristino Luigia
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Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor
Biochemical and Biophysical Research Communications, 2002Orexins (orexin A and B) are recently identified neuropeptides implicated in the regulation of vigilance states and energy homeostasis. We have shown here the physiological significance of histaminergic neurons in the orexin-induced arousal responses. Immunohistochemical and electron microscopic techniques revealed direct synaptic interaction between ...
Akihiro, Yamanaka +9 more
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Peptides, 2006
Orexin-A (hypocretin-1), a neuropeptide with stimulatory actions on arousal and appetite, was originally shown to be specifically expressed in the hypothalamus. We studied expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine.
Kazuhiro, Takahashi +7 more
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Orexin-A (hypocretin-1), a neuropeptide with stimulatory actions on arousal and appetite, was originally shown to be specifically expressed in the hypothalamus. We studied expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine.
Kazuhiro, Takahashi +7 more
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[Roles of orexin and effects of orexin receptor antagonists].
Nihon rinsho. Japanese journal of clinical medicine, 2015Orexin A and orexin B are hypothalamic neuropeptides that were discovered in 1998. Several studies suggested that orexin deficiency causes narcolepsy in humans and other mammalian species, highlighting roles of this hypothalamic neuropeptide in the regulation of sleep and wakefulness.
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