Results 181 to 190 of about 9,891 (221)
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Antagonists of the orexin receptors
Expert Opinion on Therapeutic Patents, 2006Orexin-A and orexin-B are neuropeptides that are produced by neurons in the lateral hypothalamus. These neuropeptides bind and activate two closely related G-protein-coupled receptors, orexin-1 and orexin-2, and are involved in a variety of biological functions, including feeding, sleep–wake cycle, regulation of gastric acid secretion and reward ...
Jiaqiang Cai
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Peptides, 2006
Orexin-A (hypocretin-1), a neuropeptide with stimulatory actions on arousal and appetite, was originally shown to be specifically expressed in the hypothalamus. We studied expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine.
Zenei Arihara +2 more
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Orexin-A (hypocretin-1), a neuropeptide with stimulatory actions on arousal and appetite, was originally shown to be specifically expressed in the hypothalamus. We studied expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine.
Zenei Arihara +2 more
exaly +3 more sources
Orexin Receptor Antagonists and Insomnia
Current Psychiatry Reports, 2022We review recent evidence on the use of orexin receptor antagonists (ORAs) for treating insomnia. We evaluate studies on five dual ORAs and one selective ORA.Research on suvorexant in recent years gradually focus on comorbid insomnia, while lemborexant and daridorexant were still being validated in primary insomnia.
Xin, Wu +4 more
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Orexin receptors: Targets and applications
Fundamental & Clinical Pharmacology, 2021AbstractOver the years, elucidating targets from the neural circuits that can be used to treat disorders pertaining to the nervous system and extending their scope to other systems have always proved interesting to researchers. The role of various peptides and neurotransmitters has been elucidated and is being developed as therapeutic targets.
Subhiksha Subramanian +1 more
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Journal of Medicinal Chemistry, 2004
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang +4 more
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The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang +4 more
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A molecular network map of orexin-orexin receptor signaling system
Journal of Cell Communication and Signaling, 2022Orexins are excitatory neuropeptides, which are predominantly associated with feeding behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of HCRTR1 and HCRTR2, G-protein-coupled receptors of rhodopsin family and the endogenous ligands processed from HCRT pro-hormone, Orexin A and Orexin B.
Oishi Chatterjee +9 more
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Orexins/hypocretins and orexin receptors in apoptosis: a mini‐review
Acta Physiologica, 2010AbstractAn unexpected and fascinating aspect of the neuropeptides orexins has recently emerged when it was shown that orexins acting at orexin receptors OX1R or OX2R induce dramatic apoptosis resulting in massive reduction in cell growth in various cancer cell lines.
M, Laburthe, T, Voisin, A, El Firar
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Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors
Current Opinion in Neurobiology, 2002Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in
Michihiro, Mieda, Masashi, Yanagisawa
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Pharmaceutical Patent Analyst, 2012
The orexin neuropeptides bind to two G protein-coupled receptors, orexin-1 and -2. Small-molecule antagonism of the receptors has potential therapeutic utility in a number of areas, most notably insomnia, for which the most advanced dual orexin receptor antagonist has now completed clinical trials.
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The orexin neuropeptides bind to two G protein-coupled receptors, orexin-1 and -2. Small-molecule antagonism of the receptors has potential therapeutic utility in a number of areas, most notably insomnia, for which the most advanced dual orexin receptor antagonist has now completed clinical trials.
openaire +2 more sources
Orexins and orexin receptors: implication in feeding behavior
Regulatory Peptides, 1999Orexin-A and -B are initially identified as endogenous ligands for an orphan G protein coupled receptor. Since the discovery of orexins, investigations of their functions have been guided by their distribution in the lateral hypothalamic area, which has been implicated in feeding behavior.
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