Results 201 to 210 of about 9,891 (221)

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Psychopharmacology, 2001
Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine ...
D N, Jones, J, Gartlon, F, Parker, S G, Taylor, C, Routledge, P, Hemmati, R P, Munton, T E, Ashmeade, J P, Hatcher, A, Johns, R A, Porter, J J, Hagan, A J, Hunter, N, Upton   +13 more
openaire   +2 more sources

Small-molecule Antagonists of the Orexin Receptors

Pharmaceutical Patent Analyst, 2014
The orexin-1 and orexin-2 receptors are two G protein-coupled receptors that bind the neuropeptides orexin-A and orexin-B. Dual antagonism of the receptors by small molecules is clinically efficacious in the treatment of insomnia, where the most advanced molecule suvorexant has recently been approved.
openaire   +2 more sources

[Roles of orexin and effects of orexin receptor antagonists].

Nihon rinsho. Japanese journal of clinical medicine, 2015
Orexin A and orexin B are hypothalamic neuropeptides that were discovered in 1998. Several studies suggested that orexin deficiency causes narcolepsy in humans and other mammalian species, highlighting roles of this hypothalamic neuropeptide in the regulation of sleep and wakefulness.
openaire   +1 more source

Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders

Medicinal Research Reviews, 2023
Alessandro Bonifazi, Fabio Del Bello, Gianfabio Giorgioni   +2 more
exaly  

In vivo microdialysis reveals that blockade of accumbal orexin OX 2 but not OX 1 receptors enhances dopamine efflux in the nucleus accumbens of freely moving rats

European Journal of Neuroscience, 2022
Yuri Aono, John L Waddington, Tadashi Saigusa   +2 more
exaly  

Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes

Pharmacological Reports, 2011
Agata Woldan-Tambor, Anna Wiktorowska-Owczarek, Jolanta B Zawilska   +2 more
exaly  

Role of dorsal hippocampal orexin-1 receptors in memory restoration induced by morphine sensitization phenomenon

Neuroscience, 2016
Sakineh Alijanpour, Fatemeh Tirgar, Mohammad-Reza Zarrindast   +2 more
exaly  

Role of orexin receptors in the nucleus accumbens in dopamine-dependent turning behaviour of rats

Neuropharmacology, 2008
Hiroko Ikeda, Noriaki Koshikawa, A R Cools   +2 more
exaly  

Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

Cell, 1998
Takeshi Sakurai, Makoto Ishii, Richard M Chemelli   +2 more
exaly  

Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists

European Journal of Pharmacology, 2011
Pascal Bonaventure, Michael D Hack, Steven W Sutton   +2 more
exaly