Results 91 to 100 of about 6,131 (232)
Profiling the sleep architecture of ageing adults using a seven‐state continuous‐time Markov model
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Sleep is a complex biological process regulated by networks of neurons and environmental factors. As one falls asleep, neurotransmitters from sleep–wake regulating neurones work in synergy to control the switching of different sleep states throughout the night. As sleep disorders or underlying neuropathology can manifest as irregular switching,
Jonathon Jacobs +3 more
wiley +1 more source
Orexin A-Mediated Modulation of Reproductive Activities in Testis of Normal and Cryptorchid Dogs: Possible Model for Studying Relationships Between Energy Metabolism and Reproductive Control [PDF]
, 2019 Orexin A (OxA) is a neuropeptide produced in the lateral hypothalamus that performs pleiotropic functions in different tissues, including involvement in energy homeostasis and reproductive neuroendocrine functions.
Annunziata, Chiara +5 more
core +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng +3 more
wiley +1 more source
Differential Effects of Psychological and Physical Stress on the Sleep Pattern in Rats [PDF]
, 2007 In the present study, we investigated the acute effects of 2 different kinds of stress, namely physical stress (foot shock) and psychological stress (non-foot shock) induced by the communication box method, on the sleep patterns of rats.
Araki, Hiroaki +3 more
core +1 more source
Journal of Sleep Research, EarlyView.How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads +8 more
wiley +1 more source
The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases
Frontiers in Molecular Neuroscience, 2018 Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein–coupled receptors (GPCRs), orexin ...
Chunmei Wang +8 more
doaj +1 more source
Identification and characterization of neuroendocrine pathways involved in the regulation of seasonal body weight cycles [PDF]
, 2004 Die vorliegende Dissertation beschreibt die Identifizierung und Charakterisierung von neuroendokrinen Signalwegen, die in die saisonale Körpergewichtsregulation involviert sind.
Khorooshi, Mohammad H. +1 more
core +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT This pilot observational study evaluated whether frequent overnight sampling of ventricular cerebrospinal fluid could clarify how sleep, hypocretin and lactate relate to amyloid‐β42 dynamics in adults with hydrocephalus. Seven participants underwent hourly ventricular cerebrospinal fluid sampling from early evening to late morning during ...
Casper Schwartz Riedel +4 more
wiley +1 more source
Chinese Medical Journal, 2015 Background: Sleep/wake disturbances in patients with amyotrophic lateral sclerosis (ALS) are well-documented, however, no animal or mechanistic studies on these disturbances exist.
Rong Liu +4 more
doaj +1 more source