Results 101 to 110 of about 132,160,554 (236)

On-chip maturation of induced pluripotent stem-cell derived hepatocytes

, 2017
The increasing interest in induced pluripotent stem cells (iPSCs) for research towards personalized medicine fits together well with recent advances in organ-on-chip development.
Abbaszadehbanaeiyan, Amin,, Adiels, Caroline B.,, Goksör, Mattias,, Dalsbecker, Philip,, Theobald, Jannick, Wölfl, Stefan   +5 more
core  

Towards the joint on a chip: double layered directly interfaced tissues to mimic the Osteoarthritic cartilage-subchondral interface

, 2020
Osteoarthritis (OA) is the most diffused musculoskeletal disease and a worldwide cause of pain and disability. Although OA’s most evidently affected tissue is cartilage (AC), pathological changes regard the whole joint.
Andrea Mainardi, Paola Occhetta, Andrea Barbero, Ivan Martin, Stefano Ugolini, Marco Rasponi   +5 more
core  

Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface

Engineering, 2017
Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprecedented access and insights into this ...
Marc Mac Giolla Eain, Joanna Baginska, Kacy Greenhalgh, Joëlle V. Fritz, Frederic Zenhausern, Paul Wilmes   +5 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Bioprinted 3-dimensional lung organoids for respiratory disease modeling and therapeutic applications [PDF]

Organoid
Advances in 3-dimensional (3D) lung models have created new opportunities in respiratory research, providing alternatives to conventional 2-dimensional cultures and animal models.
Jimin Jang, Se-Ran Yang
doaj   +1 more source

Graded Metallopolymer Structures with Shape‐Memory Abilities via DLP‐Based 3D‐Printing

Advanced Functional Materials, EarlyView.
This study presents the digital light processing (DLP) based 3D printing of graded metallopolymers featuring shape‐memory abilities. The permanent shape can be recovered in two distinct steps with excellent rates. The obtained graded prints range from simple rod‐like structures to complex hollow materials.
Michael Klein, Michael F. Agyemang, Michael Schmitt, Jürgen Popp, Martin D. Hager, Stefan Zechel, Ulrich S. Schubert   +6 more
wiley   +1 more source

Organ-, body- and disease-on-a-chip systems

, 2017
Thought leader Michael Shuler introduces the Lab on a Chip organ, body and disease on a chip thematic collection.
Michael L. Shuler
core   +1 more source

Additively Manufactured Geometry‐Reconfigurable Soft Neural Probes With Monolithic Multifunctionality

Advanced Functional Materials, EarlyView.
A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee, Xinyi Wang, Sirui Li, Jihyang Park, Hyunseok Lee, Jianting Yao, Kedar Narayan, Yuqi Wang, Jiashu Ren, Yueqi Deng, Salahuddin Ahmed, Denver I. Greenawalt, Archana Pandiyan, Loganathan Veeramuthu, Chi‐Ching Kuo, Tao Zhou   +15 more
wiley   +1 more source

Correction: 3D printed nervous system on a chip

, 2016
Correction for ‘3D printed nervous system on a chip’ by Blake N.
Meng, Fanben, Johnson, Blake N, McAlpine, Michael C, Lancaster, Karen Z, Enquist, Lynn W, Hogue, Ian B, Kong, Yong Lin   +6 more
core   +1 more source

Advancing intestinal disease research using gut-on-a-chip

Regenerative Therapy
The intestine is exposed constantly to mechanical stimuli, including blood flow or peristalsis. Recently, gut-on-a-chip models have been developed to recapitulate these physiological stresses.
Fuki Yokoi, Sayaka Deguchi, Kazuo Takayama   +2 more
doaj   +1 more source