Results 1 to 10 of about 210,372 (257)

Perfusable micro-vascularized 3D tissue array for high-throughput vascular phenotypic screening

Nano Convergence, 2022
Microfluidic organ-on-a-chip technologies have enabled construction of biomimetic physiologically and pathologically relevant models. This paper describes an injection molded microfluidic platform that utilizes a novel sequential edge-guided patterning ...
James Yu, Somin Lee, Jiyoung Song, Seung-Ryeol Lee, Suryong Kim, Hyeri Choi, Habin Kang, Yunchan Hwang, Young-Kwon Hong, Noo Li Jeon   +9 more
doaj   +1 more source

Host-microbe-cancer interactions on-a-chip

Frontiers in Bioengineering and Biotechnology
The tumor microbiota has emerged as a pivotal contributor to a variety of cancers, impacting disease development, progression, and therapeutic resistance.
Mauricio G. C. Sousa, Mauricio G. C. Sousa, Mauricio G. C. Sousa, Danielle S. K. Brasino, Madeline Krieger, Duygu A. Dindar, Rebekka Duhen, Rebekka Duhen, Zhenzhen Zhang, Cristiane Miranda Franca, Cristiane Miranda Franca, Cristiane Miranda Franca, Luiz E. Bertassoni, Luiz E. Bertassoni, Luiz E. Bertassoni, Luiz E. Bertassoni, Luiz E. Bertassoni   +16 more
doaj   +1 more source

Recent advances in 3D-printing-based organ-on-a-chip

EngMedicine
Organ-on-a-chip (OOC) facilitates precise manipulation of fluids in microfluidic chips and simulation of the physiological, chemical, and mechanical characteristics of tissues, thus providing a promising tool for in vitro drug screening and physiological
Xinkun Wu, Wenwan Shi, Xiaojiang Liu, Zhongze Gu   +3 more
doaj   +1 more source

The tumor microenvironment in therapy resistance

Frontiers in Lab on a Chip Technologies
Chemotherapy alone or in conjunction with surgery and radiation is often used to treat various cancer types. While effective at treating some tumors, the response varies across patients with different malignancies. For some cancers, such as glioblastoma,
Guadalupe G. Garcia, Christopher J. Schmidt, Cynthia Hajal, Cynthia Hajal, Cynthia Hajal   +4 more
doaj   +1 more source

Biomimetic electrospun scaffolds for engineered heart tissue: from design parameters to drug testing platforms

Frontiers in Bioengineering and Biotechnology
Electrospun nanofibers have emerged as a promising platform for cardiac tissue engineering, offering unique opportunities to recapitulate the native myocardial extracellular matrix (ECM) architecture.
Raminta Vaiciuleviciute, Aidas Alaburda, Ilona Uzieliene, Kornél Kistamás, Máté Lengyel, András Dinnyés, András Dinnyés, Christian Bergaud, Eiva Bernotiene, Eiva Bernotiene   +9 more
doaj   +1 more source

Next-Generation Joint-on-a-Chip: Toward Precision Mechanical Control in Multi-Tissue Systems

Nano-Micro Letters
Highlights Outlines key structural and microenvironmental features of joints. Discusses strategies to integrate mechanical stimulation with multi-tissue co-culture. Proposes innovative design concepts toward next-generation joint-on-a-chip platforms.
Zhenjun Lv, Yuwei Chai, Xiumei Zhang, Weiwei Lan, Junchao Wei, Lu Li, Weiyi Chen, Yiting Lei, Jun Liu, Zhong Alan Li, Di Huang   +10 more
doaj   +1 more source

The recent development and applications of fluidic channels by 3D printing

Journal of Biomedical Science, 2017
The technology of “Lab-on-a-Chip” allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries.
Yufeng Zhou
doaj   +1 more source

Advances in 3D Bioprinting: Materials, Processes, and Emerging Applications

Micromachines
Three-dimensional (3D) bioprinting has rapidly emerged as a transformative technology at the interface of biomedical engineering and regenerative medicine.
Subin Antony Jose, Antonia Evtimow, Pradeep L. Menezes   +2 more
doaj   +1 more source

The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review

Micromachines, 2020
In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury.
Alican Özkan, Danielle Stolley, Erik N. K. Cressman, Matthew McMillin, Sharon DeMorrow, Thomas E. Yankeelov, Marissa Nichole Rylander   +6 more
doaj   +1 more source

Bioprinting-Based High-Throughput Fabrication of Three-Dimensional MCF-7 Human Breast Cancer Cellular Spheroids

Engineering, 2015
Cellular spheroids serving as three-dimensional (3D) in vitro tissue models have attracted increasing interest for pathological study and drug-screening applications.
Kai Ling, Guoyou Huang, Juncong Liu, Xiaohui Zhang, Yufei Ma, Tianjian Lu, Feng Xu   +6 more
doaj   +1 more source