Results 11 to 20 of about 210,372 (257)

Advances and Applications of Organ-on-a-Chip and Tissue-on-a-Chip Technology [PDF]

Bioengineering
Organ-on-a-chip (OoC) or tissue-on-a-chip (ToC) technologies represent a significant advancement in enabling modeling of human organ and tissue physiology for medical study, although further development is required for these technologies to reach ...
Megan Moore, Sashwat Sriram, Jennifer Ku, Yong Li   +3 more
doaj   +5 more sources

Osteochondral Tissue-On-a-Chip: A Novel Model for Osteoarthritis Research. [PDF]

Int J Mol Sci
The existing in vitro and in vivo models for studying osteoarthritis have significant limitations in replicating the complexity of joint tissues. This research aims to validate a Tissue-On-a-Chip system for osteoarthritis research. Osteochondral tissues obtained from knee replacement surgeries of patients with osteoarthritis were cultured in an Organ ...
González-Guede I, Garriguez-Perez D, Fernandez-Gutierrez B.   +2 more
europepmc   +6 more sources

Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing

Micromachines, 2021
Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies.
Leslie Donoghue, Khanh T. Nguyen, Caleb Graham, Palaniappan Sethu   +3 more
doaj   +3 more sources

Tissue Barrier-on-Chip: A Technology for Reproducible Practice in Drug Testing. [PDF]

Pharmaceutics, 2022
One key application of organ-on-chip systems is the examination of drug transport and absorption through native cell barriers such the blood–brain barrier. To overcome previous hurdles related to the transferability of existing static cell cultivation protocols and polydimethylsiloxane (PDMS) as the construction material, a chip platform with key ...
Koch EV, Ledwig V, Bendas S, Reichl S, Dietzel A.   +4 more
europepmc   +4 more sources

Tissue-on-a-Chip: Microphysiometry With Human 3D Models on Transwell Inserts. [PDF]

Front Bioeng Biotechnol, 2020
Microphysiometry has proved to be a useful tool for monitoring the energy metabolism of living cells and their interactions with other cells. The technique has mainly been used for monitoring two-dimensional (2D) monolayers of cells. Recently, our group showed that it is also possible to monitor the extracellular acidification rate and transepithelial ...
Schmidt C, Markus J, Kandarova H, Wiest J.   +3 more
europepmc   +5 more sources

Evaluating Complexity in Orthopedic Tissue-on-a-Chip Systems. [PDF]

Adv Healthc Mater
Abstract Orthopedic tissue‐on‐a‐chip systems are rapidly emerging to model tissue homeostasis and disease, including to screen new therapeutics. These platforms range in complexity, related to the number of cells, materials, and other factors that are introduced into their design, which may influence their ability to mimic tissue ...
Zlotnick HM, Goddard DN, Burdick JA.
europepmc   +4 more sources

Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue-on-a-Chip for Drug Screening. [PDF]

Small Methods, 2020
AbstractAnimal models and traditional cell cultures are essential tools for drug development. However, these platforms can show striking discrepancies in efficacy and side effects when compared to human trials. These differences can lengthen the drug development process and even lead to drug withdrawal from the market.
Ren L, Zhou X, Nasiri R, Fang J, Jiang X, Wang C, Qu M, Ling H, Chen Y, Xue Y, Hartel MC, Tebon P, Zhang S, Kim HJ, Yuan X, Shamloo A, Dokmeci MR, Li S, Khademhosseini A, Ahadian S, Sun W.   +20 more
europepmc   +6 more sources

Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. [PDF]

Toxicol In Vitro, 2020
Kidney is a major route of xenobiotic excretion, but the accuracy of preclinical data for predicting in vivo clearance is limited by species differences and non-physiologic 2D culture conditions. Microphysiological systems can potentially increase predictive accuracy due to their more realistic 3D environment and incorporation of dynamic flow.
Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA.   +9 more
europepmc   +4 more sources

Glioma-on-a-Chip Models

Micromachines, 2021
Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Sultan Ilci, Tugba Bagci-Onder, Savas Tasoglu   +4 more
doaj   +1 more source

Three-Dimensional-Bioprinted Liver Chips and Challenges

Applied Sciences, 2022
Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh, Berin Ozdalgic, Nur Mustafaoglu, Savas Tasoglu   +3 more
doaj   +1 more source