Results 31 to 40 of about 132,160,554 (236)
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture [PDF]
, 2022 S.3538-3547Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity.
Lauster, R. +11 more
core +2 more sources
Aggregate, 2023 Organ‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures.
Sajjad Rahmani Dabbagh +5 more
doaj +1 more source
Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
Micromachines, 2021 Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies.
Leslie Donoghue +3 more
doaj +1 more source
Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery
Pharmaceutics, 2023 Drug discovery is an expensive, long, and complex process, usually with a high degree of uncertainty. In order to improve the efficiency of drug development, effective methods are demanded to screen lead molecules and eliminate toxic compounds in the ...
Jingyu Fu, Hailong Qiu, Cherie S. Tan
doaj +1 more source
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]
, 2017 Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Drewell, Christopher +13 more
core +2 more sources
Microfluidic-Chip-Integrated Biosensors for Lung Disease Models
Biosensors, 2021 Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs.
Shuang Ding, Haijun Zhang, Xuemei Wang
doaj +1 more source
3D Inkjet-Bioprinted Lung-on-a-Chip
, 2023 There is an urgent need for physiologically relevant and customizable biochip models of human lung tissue to provide a niche for lung disease modeling and drug efficacy.
Dayoon Kang +11 more
core +1 more source
Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity
Bioactive Materials, 2021 Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
doaj +1 more source
, 2022 S.1866-1885Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex fabrication ...
Schneider, S. +3 more
core +1 more source
Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)
Frontiers in Cell and Developmental Biology, 2021 Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases.
Mridu Malik +6 more
doaj +1 more source