Results 11 to 20 of about 61,131 (327)
Experimental Cell Research, 2018 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The physiological importance and plasticity
Beckwitt, Colin H. +6 more
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One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology. [PDF]
Lab on a Chip, 2016 Although various types of organs-on-chips have been introduced recently as tools for drug discovery, the current studies are limited in terms of fabrication methods.
Hyungseok Lee, D. Cho
semanticscholar +3 more sources
Bioengineering, 2023 This paper presents an innovative experimental setup that employs the principles of audio technology to subject adherent cells to rhythmic vertical vibrations.
Dongho Kwak +3 more
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Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
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A directional 3D neurite outgrowth model for studying motor axon biology and disease
Scientific Reports, 2021 We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel,
Xandor M. Spijkers +5 more
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Open Research Europe, 2023 It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational ...
Giulia Malaguarnera +2 more
doaj +1 more source
Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
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Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
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Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022 Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip studies in recent years. These chips have many advantages such as high efficiency, low sample consumption, fast analysis, durability and low cost.
Fatma Doğan Guzel +2 more
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Recent advances in vascularized tumor-on-a-chip
Frontiers in Oncology, 2023 The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of ...
Christina Bao Xian Huang +3 more
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