Results 261 to 270 of about 67,848,505 (299)
Organ-on-chip platforms for nanoparticle toxicity and efficacy assessment: Advancing beyond traditional in vitro and in vivo models. [PDF]
Mater Today BioSampaio AR +4 more
europepmc +1 more source
Artificial intelligence-, organoid-, and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges. [PDF]
Front Artif IntellElfatimi E +12 more
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Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis. [PDF]
Open BiolKoceva H +10 more
europepmc +1 more source
Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling. [PDF]
J Transl MedLiu B +6 more
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Nature Biotechnology, 2014
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular ...
Sangeeta N, Bhatia, Donald E, Ingber
openaire +2 more sources
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular ...
Sangeeta N, Bhatia, Donald E, Ingber
openaire +2 more sources
Asian Journal of Pharmacy and Technology, 2021
A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in ...
Rathod Pallavi Vasant +3 more
openaire +1 more source
A multichannel three-dimensional chip of a microfluidic cell culture which enables the simulation of organs is called an “organ on a chip” (OC). With the integration of many other technologies, OCs have been mimicking organs, substituting animal models, and diminishing the time and cost of experiments which is better than the preceding conventional in ...
Rathod Pallavi Vasant +3 more
openaire +1 more source
Microfabrication of human organs-on-chips
Nature Protocols, 2013'Organs-on-chips' are microengineered biomimetic systems containing microfluidic channels lined by living human cells, which replicate key functional units of living organs to reconstitute integrated human organ-level pathophysiology in vitro. These microdevices can be used to test efficacy and toxicity of drugs and chemicals, and to create in vitro ...
Dongeun, Huh +7 more
openaire +2 more sources
2016
The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
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The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
openaire +1 more source
Cell Host and Microbe, 2021
The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human interspecies differences has prompted the development of sophisticated in vitro models of human gut-microbe interactions. Here, we review
Puschhof, Jens +2 more
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The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The difficulty of inferring causation from metagenomic microbiome sequencing studies and from mouse-human interspecies differences has prompted the development of sophisticated in vitro models of human gut-microbe interactions. Here, we review
Puschhof, Jens +2 more
openaire +1 more source