Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers. [PDF]
PLoS ONE, 2012 In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss. The underlying cause for the lack of regenerative response is the depletion of otic progenitors in the cell pool of the sensory ...
Jörg Waldhaus +5 more
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Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance Mammalian cochlear amplification is subserved by electromotile outer hair cells (OHCs) cradled within the organ of Corti by a complex, interlocking cellular scaffold whose functional significance cries out for explanation; and, indeed, the ...
Shera CA, Altoè A.
europepmc +2 more sources
Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti. [PDF]
J Acoust Soc Am, 2022 The mammalian ear embeds a cellular amplifier that boosts sound-induced hydromechanical waves as they propagate along the cochlea. The operation of this amplifier is not fully understood and is difficult to disentangle experimentally.
Altoè A +4 more
europepmc +2 more sources
Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. [PDF]
PLoS ONE, 2012 In the mammalian inner ear neurosensory cell fate depends on three closely related transcription factors, Atoh1 for hair cells and Neurog1 and Neurod1 for neurons.
Israt Jahan +8 more
doaj +4 more sources
Using volumetric optical coherence tomography to achieve spatially resolved organ of Corti vibration measurements. [PDF]
J Acoust Soc Am, 2022 Optical coherence tomography (OCT) has become a powerful tool for measuring vibrations within the organ of Corti complex (OCC) in cochlear mechanics experiments.
Frost BL, Strimbu CE, Olson ES.
europepmc +2 more sources
Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance The remarkable high-frequency sensitivity of mammalian hearing depends on the amplification of sound-evoked cochlear vibrations by outer hair cells.
Dewey JB +4 more
europepmc +2 more sources
A flexible anatomical set of mechanical models for the organ of Corti. [PDF]
R Soc Open Sci, 2021 We built a flexible platform to study the mechanical operation of the organ of Corti (OoC) in the transduction of basilar membrane (BM) vibrations to oscillations of an inner hair cell bundle (IHB). The anatomical components that we consider are the outer hair cells (OHCs), the outer hair cell bundles, Deiters cells, Hensen cells, the IHB and various ...
Berger J, Rubinstein J.
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Frontiers in Cellular Neuroscience, 2018 We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and ...
Karen L. Elliott +2 more
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Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning
eLife, 2019 The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map
Shinji Urata +7 more
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Consequences of Location-Dependent Organ of Corti Micro-Mechanics. [PDF]
PLoS ONE, 2015 The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is
Yanju Liu +2 more
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