Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival [PDF]
Frontiers in ImmunologyMacrophages are the primary immune cells in the cochlea, essential for maintaining cochlear homeostasis and orchestrating inflammatory responses to pathological events.
Mengxiao Ye +6 more
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Organ of Corti vibrations are dominated by longitudinal motion in vivo [PDF]
Communications Biology, 2022 Multi-angle optical coherence tomography measurements link organ of Corti vibrations to complex motions in inner-ear sound processing.
Sebastiaan W. F. Meenderink, Wei Dong
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Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti [PDF]
Frontiers in Neuroscience, 2023 Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture ...
Laura A. Lindner +3 more
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A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae [PDF]
Scientific ReportsFKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus.
Asuka Sato +3 more
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Cochlea cell-specific marker expression upon in vitro Hes1 knockdown [PDF]
Brazilian Journal of Medical and Biological Research, 2021 NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from
A.C. Batissoco +9 more
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Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation
Redox Report, 2023 Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity.
Masahiro Adachi +5 more
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Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro. [PDF]
PLoS ONE, 2016 The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age.
Mohamed Bassiouni +4 more
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Consequences of Location-Dependent Organ of Corti Micro-Mechanics. [PDF]
PLoS ONE, 2015 The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is
Yanju Liu +2 more
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Cochlear Development; New Tools and Approaches
Frontiers in Cell and Developmental Biology, 2022 The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of at least seven unique cell types including two functionally distinct types of mechanosensory hair cells.
Matthew W. Kelley
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mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening
Biomedicines, 2022 The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing and deafened guinea pigs,
Annamaria Tisi +4 more
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