Results 1 to 10 of about 166,078,283 (220)

Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice. [PDF]

PLoS ONE, 2015
Tricellular tight junctions seal the extracellular spaces of tricellular contacts, where the vertices of three epithelial cells meet, and are required for the establishment of a strong barrier function of the epithelial cellular sheet.
Tomohito Higashi, Tatsuya Katsuno, Shin-Ichiro Kitajiri, Mikio Furuse   +3 more
doaj   +1 more source

Behavioral characteristics in sensing mechanism of the Corti

Computational and Structural Biotechnology Journal, 2023
Some experiments can’t be realized because the cochlea’s Corti is the most delicate and complex sensory organ. In this paper, some typical and special behavioral characteristics in the process of sensation were found in medical clinic.
Junyi Liang, Jiakun Wang, Wenjuan Yao, Lei Zhou, Xinsheng Huang   +4 more
doaj   +1 more source

Expression of S100β during mouse cochlear development

European Journal of Histochemistry
In the present study, the expression of S100β was examined in the mouse cochlea from embryonic day 17 (E17) to postnatal day 32 (P32) using immunofluorescence, aiming to explore its possible role in auditory system.
Wenjing Liu, Yongchun Zhang, Cheng Liang, Lizhong Su   +3 more
doaj   +1 more source

Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea

Journal of Translational Medicine, 2010
Background Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss.
Haddad Luciana A, Mingroni-Netto Regina C, Lezirovitz Karina, Batissoco Ana, Barboza-Junior Luiz, Oiticica Jeanne, Bento Ricardo F   +6 more
doaj   +1 more source

Static length changes of cochlear outer hair cells can tune low-frequency hearing.

PLoS Computational Biology, 2018
The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović, Rebecca L Warren, Batu Keçeli, Stefan Jacob, Anders Fridberger, Tobias Reichenbach   +5 more
doaj   +1 more source

Six1 is essential for differentiation and patterning of the mammalian auditory sensory epithelium.

PLoS Genetics, 2017
The organ of Corti in the cochlea is a two-cell layered epithelium: one cell layer of mechanosensory hair cells that align into one row of inner and three rows of outer hair cells interdigitated with one cell layer of underlying supporting cells along ...
Ting Zhang, Jinshu Xu, Pascal Maire, Pin-Xian Xu   +3 more
doaj   +1 more source

Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro

BMC Neuroscience, 2011
Background Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects.
Brand Yves, Setz Cristian, Levano Soledad, Listyo Alwin, Chavez Eduardo, Pak Kwang, Sung Michael, Radojevic Vesna, Ryan Allen F, Bodmer Daniel   +9 more
doaj   +1 more source

Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing

Neurobiology of Disease, 2015
Mutations in the Gjb2 gene, which encodes a gap junction protein connexin26 (Cx26), are the most prevalent form of hereditary deafness in humans and represent about half of non-syndromic congenital deafness cases in many ethnic populations.
Qing Chang, Wenxue Tang, Yeunjung Kim, Xi Lin   +3 more
doaj   +1 more source

Dye coupling in the organ of Corti

Cell and Tissue Research, 1986
Dye-coupling in an in vitro preparation of the supporting cells of the guinea-pig organ of Corti was evaluated by use of the fluorescent dyes, Lucifer Yellow, fluorescein and 6 carboxyfluorescein. Despite the presence of good electrical coupling in Hensen cells (coupling ratios greater than 0.6) the spread of Lucifer yellow was inconsistent.
openaire   +3 more sources

IGF-1 Mediated Neuroprotective Effects of Olfactory-Derived Mesenchymal Stem Cells on Auditory Hair Cells

Journal of Otolaryngology - Head and Neck Surgery
Importance Mesenchymal stem cells (MSCs) have the capability of providing ongoing paracrine support to degenerating tissues. Since MSCs can be extracted from a broad range of tissues, their specific surface marker profiles and growth factor secretions ...
Marc J. W. Lammers MD, PhD, Emily Young MD, Anat Yanai PhD, Ishaq A. Viringipurampeer PhD, Trung N. Le MD, PhD, Louise V. Straatman MD, PhD, Brian D. Westerberg MD, FRCSC, MHSc, Kevin Gregory-Evans MD, PhD, FRCSC   +7 more
doaj   +1 more source