Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers. [PDF]
PLoS ONE, 2012 In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss. The underlying cause for the lack of regenerative response is the depletion of otic progenitors in the cell pool of the sensory ...
Jörg Waldhaus +5 more
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Organ of Corti vibrations are dominated by longitudinal motion in vivo [PDF]
Communications Biology, 2022 Multi-angle optical coherence tomography measurements link organ of Corti vibrations to complex motions in inner-ear sound processing.
Sebastiaan W. F. Meenderink, Wei Dong
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Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance Mammalian cochlear amplification is subserved by electromotile outer hair cells (OHCs) cradled within the organ of Corti by a complex, interlocking cellular scaffold whose functional significance cries out for explanation; and, indeed, the ...
Shera CA, Altoè A.
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Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti. [PDF]
J Acoust Soc Am, 2022 The mammalian ear embeds a cellular amplifier that boosts sound-induced hydromechanical waves as they propagate along the cochlea. The operation of this amplifier is not fully understood and is difficult to disentangle experimentally.
Altoè A +4 more
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Using volumetric optical coherence tomography to achieve spatially resolved organ of Corti vibration measurements. [PDF]
J Acoust Soc Am, 2022 Optical coherence tomography (OCT) has become a powerful tool for measuring vibrations within the organ of Corti complex (OCC) in cochlear mechanics experiments.
Frost BL, Strimbu CE, Olson ES.
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Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning
eLife, 2019 The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map
Shinji Urata +7 more
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Frontiers in Cellular Neuroscience, 2018 We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and ...
Karen L. Elliott +2 more
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Mechanically facilitated micro-fluid mixing in the organ of Corti. [PDF]
Sci Rep, 2020 The cochlea is filled with two lymphatic fluids. Homeostasis of the cochlear fluids is essential for healthy hearing. The sensory epithelium called the organ of Corti separates the two fluids. Corti fluid space, extracellular fluid space within the organ
Shokrian M, Knox C, Kelley DH, Nam JH.
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Consequences of Location-Dependent Organ of Corti Micro-Mechanics. [PDF]
PLoS ONE, 2015 The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is
Yanju Liu +2 more
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Significance of the Microfluidic Flow Inside the Organ of Corti. [PDF]
J Biomech Eng, 2020 We study the vibration modes of a short section in the middle turn of the gerbil cochlea including both longitudinal and radial interstitial fluid spaces between the pillar cells and hair cells to determine the role of the interstitial fluid flow within ...
Zagadou BF, Barbone PE, Mountain DC.
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