Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival [PDF]
Frontiers in ImmunologyMacrophages are the primary immune cells in the cochlea, essential for maintaining cochlear homeostasis and orchestrating inflammatory responses to pathological events.
Mengxiao Ye +6 more
doaj +2 more sources
A multiscale model of the organ of Corti [PDF]
Journal of Mechanics of Materials and Structures, 2009 The organ of Corti is the sensory epithelium in the cochlea of the inner ear. It is modeled as a shell-of-revolution structure with continuous and discrete components. Our recent work has been on the inclusion of the viscous fluid. Measurements from various laboratories provide the opportunity to refocus on the elastic properties.
Charles R. Steele +2 more
openalex +3 more sources
Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers. [PDF]
PLoS ONE, 2012 In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss. The underlying cause for the lack of regenerative response is the depletion of otic progenitors in the cell pool of the sensory ...
Jörg Waldhaus +5 more
doaj +3 more sources
Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. [PDF]
PLoS ONE, 2016 The organ of Corti has evolved a panoply of cells with extraordinary morphological specializations to harness, direct, and transduce mechanical energy into electrical signals.
Lana M Pollock +4 more
doaj +3 more sources
Organ of Corti vibrations are dominated by longitudinal motion in vivo [PDF]
Communications Biology, 2022 Multi-angle optical coherence tomography measurements link organ of Corti vibrations to complex motions in inner-ear sound processing.
Sebastiaan W. F. Meenderink, Wei Dong
doaj +2 more sources
Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti [PDF]
Frontiers in Neuroscience, 2023 Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture ...
Laura A. Lindner +3 more
doaj +2 more sources
Preparation of the intact rodent organ of Corti for RNAscope and immunolabeling, confocal microscopy, and quantitative analysis [PDF]
STAR Protocols, 2021 Summary: This protocol describes the preparation of the mouse organ of Corti for RNAscope, immunolabeling, confocal microscopy, and quantitative image analysis to examine transcript and protein localization, sensory hair cells, and synapses.
Daniel O.J. Reijntjes +3 more
doaj +2 more sources
A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae [PDF]
Scientific ReportsFKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus.
Asuka Sato +3 more
doaj +2 more sources
Modelling motions within the organ of Corti [PDF]
AIP Conference Proceedings, 2015 Most cochlear models used to describe the basilar membrane vibration along the cochlea are concerned with macromechanics, and often assume that the organ of Corti moves as a single unit, ignoring the individual motion of different components. New experimental technologies provide the opportunity to measure the dynamic behaviour of different components ...
Guangjian Ni +2 more
openalex +3 more sources
eLife, 2016 The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti.
Martin L Basch +13 more
doaj +2 more sources