Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancers. [PDF]
PLoS ONE, 2012 In the adult mammalian auditory epithelium, the organ of Corti, loss of sensory hair cells results in permanent hearing loss. The underlying cause for the lack of regenerative response is the depletion of otic progenitors in the cell pool of the sensory ...
Jörg Waldhaus +5 more
doaj +16 more sources
A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae [PDF]
Scientific ReportsFKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus.
Asuka Sato +3 more
doaj +4 more sources
A flexible anatomical set of mechanical models for the organ of Corti. [PDF]
R Soc Open Sci, 2021 We built a flexible platform to study the mechanical operation of the organ of Corti (OoC) in the transduction of basilar membrane (BM) vibrations to oscillations of an inner hair cell bundle (IHB). The anatomical components that we consider are the outer hair cells (OHCs), the outer hair cell bundles, Deiters cells, Hensen cells, the IHB and various ...
Berger J, Rubinstein J.
europepmc +2 more sources
Organ of Corti vibrations are dominated by longitudinal motion in vivo [PDF]
Communications Biology, 2022 Multi-angle optical coherence tomography measurements link organ of Corti vibrations to complex motions in inner-ear sound processing.
Sebastiaan W. F. Meenderink, Wei Dong
doaj +2 more sources
Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti [PDF]
Frontiers in Neuroscience, 2023 Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture ...
Laura A. Lindner +3 more
doaj +2 more sources
Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling
BMC Neuroscience, 2011 Background Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects.
Brand Yves +9 more
doaj +6 more sources
Preparation of the intact rodent organ of Corti for RNAscope and immunolabeling, confocal microscopy, and quantitative analysis [PDF]
STAR Protocols, 2021 Summary: This protocol describes the preparation of the mouse organ of Corti for RNAscope, immunolabeling, confocal microscopy, and quantitative image analysis to examine transcript and protein localization, sensory hair cells, and synapses.
Daniel O.J. Reijntjes +3 more
doaj +2 more sources
Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea [PDF]
Journal of Translational Medicine, 2010 Background Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss.
Haddad Luciana A +6 more
doaj +4 more sources
Cell Type-Specific Reduction of Beta Tubulin Isotypes Synthesized in the Developing Gerbil Organ of Corti [PDF]
, 2003 There are seven isotypic forms of the microtubule protein beta tubulin in mammals, but not all isotypes are synthesized in every cell type. In the adult organ of Corti, each of the five major cell types synthesizes a different subset of isotypes.
Eley, Jonquille +4 more
core +4 more sources
Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. [PDF]
PLoS ONE, 2016 The organ of Corti has evolved a panoply of cells with extraordinary morphological specializations to harness, direct, and transduce mechanical energy into electrical signals.
Lana M Pollock +4 more
doaj +3 more sources