Results 31 to 40 of about 17,899 (265)
Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro. [PDF]
PLoS ONE, 2016 The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age.
Mohamed Bassiouni +4 more
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Cochlear Development; New Tools and Approaches
Frontiers in Cell and Developmental Biology, 2022 The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of at least seven unique cell types including two functionally distinct types of mechanosensory hair cells.
Matthew W. Kelley
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Journal of Cellular and Molecular Medicine, 2020 Ferroptosis is a recently recognized form of non‐apoptotic cell death caused by an iron‐dependent accumulation of lipid hydroperoxides, which plays important roles in a wide spectrum of pathological conditions.
Honglin Mei +6 more
semanticscholar +1 more source
mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening
Biomedicines, 2022 The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing and deafened guinea pigs,
Annamaria Tisi +4 more
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A multiscale model of the organ of Corti [PDF]
Journal of Mechanics of Materials and Structures, 2009 The organ of Corti is the sensory epithelium in the cochlea of the inner ear. It is modeled as a shell-of-revolution structure with continuous and discrete components. Our recent work has been on the inclusion of the viscous fluid. Measurements from various laboratories provide the opportunity to refocus on the elastic properties.
Jacques Boutet de Monvel +2 more
openaire +2 more sources
PLoS Biology, 2012 A large proportion of age-related hearing loss is caused by loss or damage to outer hair cells in the organ of Corti. The organ of Corti is the mechanosensory transducing apparatus in the inner ear and is composed of inner hair cells, outer hair cells ...
Sung-Ho Huh +3 more
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Disease Models & Mechanisms, 2018 Mutations in the GJB2 gene [which encodes connexin 26 (Cx26)] are the most common causes of hereditary hearing loss in humans, and previous studies showed postnatal development arrest of the organ of Corti in different Cx26-null mouse models.
Sen Chen +7 more
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Brain Sciences, 2021 We investigated whether treatment with brain-derived neurotrophic factor (BDNF), which is known to protect spiral ganglion cells (SGCs), could also protect hair cells (HCs) and supporting cells (SCs) in the organ of Corti of a guinea pig model of ...
Annamaria Tisi +5 more
doaj +1 more source
Organ of Corti Kinematics [PDF]
JARO - Journal of the Association for Research in Otolaryngology, 2003 The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model. It is shown that, due to the lever system embodied in the organ of Corti, there is a significant transformer gain between basilar membrane and cilia displacements.
openaire +2 more sources
MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5
Cell Reports, 2015 The organ of Corti, the auditory organ of the mammalian inner ear, contains sensory hair cells and supporting cells that arise from a common sensory progenitor. The molecular bases allowing the specification of these progenitors remain elusive.
Aurélia Huyghe +9 more
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