Results 31 to 40 of about 38,316 (263)
Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning
eLife, 2019 The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map
Shinji Urata +7 more
doaj +1 more source
Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
core +1 more source
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]
, 2006 Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core +1 more source
Organ of Corti Kinematics [PDF]
JARO - Journal of the Association for Research in Otolaryngology, 2003 The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model. It is shown that, due to the lever system embodied in the organ of Corti, there is a significant transformer gain between basilar membrane and cilia displacements.
openaire +2 more sources
MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5
Cell Reports, 2015 The organ of Corti, the auditory organ of the mammalian inner ear, contains sensory hair cells and supporting cells that arise from a common sensory progenitor. The molecular bases allowing the specification of these progenitors remain elusive.
Aurélia Huyghe +9 more
doaj +1 more source
FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea [PDF]
, 2002 Neural transmission of complex sounds demands fast and sustained rates of synaptic release from the primary cochlear receptors, the inner hair cells (IHCs). The cells therefore require efficient membrane recycling.
Ashmore, JF +2 more
core +1 more source
Modeling of the Organ of Corti
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2002 Masayoshi Ando, Hiroshi Wada
openalex +3 more sources
Brazilian Journal of Otorhinolaryngology, 2009 The medial olivocochlear tract has efferent control over the outer hair cells, regulating the slow contractions and damping the fast ones. Using ipsilateral, contralateral or bilateral otoacoustic emissions amplitude studies, it is possible to estimate ...
Jerusa Roberta Massola de Oliveira +2 more
doaj +1 more source
Effects of lesions of the organ of corti on hearing [PDF]
Acta Oto-Laryngologica, 2022 Lesions causing changes in the microstructure of the organ of Corti may lead to hearing impairment.The aim of this study was to investigate the effect of various structural lesions on the organ of Corti and the auditory function.A finite element method of the cochlea and the organ of Corti were established based on computed tomography scanning and ...
Wenjuan Yao +5 more
openaire +2 more sources
Two passive mechanical conditions modulate power generation by the outer hair cells.
PLoS Computational Biology, 2017 In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex of the cochlea.
Yanju Liu +2 more
doaj +1 more source