MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5
Cell Reports, 2015 The organ of Corti, the auditory organ of the mammalian inner ear, contains sensory hair cells and supporting cells that arise from a common sensory progenitor. The molecular bases allowing the specification of these progenitors remain elusive.
Aurélia Huyghe +9 more
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Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function [PDF]
, 2017 Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Carrer, Andrea +16 more
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Organ of Corti Kinematics [PDF]
JARO - Journal of the Association for Research in Otolaryngology, 2003 The internal workings of the organ of Corti and their relation to basilar membrane motion are examined with the aid of a simple kinematic model. It is shown that, due to the lever system embodied in the organ of Corti, there is a significant transformer gain between basilar membrane and cilia displacements.
openaire +2 more sources
Brazilian Journal of Otorhinolaryngology, 2009 The medial olivocochlear tract has efferent control over the outer hair cells, regulating the slow contractions and damping the fast ones. Using ipsilateral, contralateral or bilateral otoacoustic emissions amplitude studies, it is possible to estimate ...
Jerusa Roberta Massola de Oliveira +2 more
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Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea [PDF]
, 2019 During cochlear development, hair cells (HCs) and supporting cells differentiate in the prosensory domain to form the organ of Corti, but how one row of inner HCs (IHCs) and three rows of outer HCs (OHCs) are organized is not well understood.
Hirashima, Tsuyoshi +5 more
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Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]
, 2015 Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Duchen, MR, Gale, JE, Majumder, P
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Two passive mechanical conditions modulate power generation by the outer hair cells.
PLoS Computational Biology, 2017 In the mammalian cochlea, small vibrations of the sensory epithelium are amplified due to active electro-mechanical feedback of the outer hair cells. The level of amplification is greater in the base than in the apex of the cochlea.
Yanju Liu +2 more
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Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Frontiers in Cell and Developmental Biology, 2021 Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea.
María Beatriz Durán Alonso +10 more
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Mouse Embryonic Fibroblasts-Derived Extracellular Matrix Facilitates Expansion of Inner Ear-Derived Cells [PDF]
Cell Journal, 2023 Objective: Previous reports showed that mouse embryonic fibroblasts (MEFs) could support pluripotent stem cell selfrenewaland maintain their pluripotency.
Junming Zhang +4 more
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The outer hair cell of the organ of Corti possesses a voltage-dependent motile frequency response: evidence for the frequency-dependent compliance of prestin [PDF]
J Gen Physiol. 2019 Dec 2;151(12):1369-1385, 2018 The outer hair cell (OHC) of the organ of Corti underlies a mechanically based process that enhances hearing, termed cochlear amplification. The cell possesses a unique motor protein, prestin, which senses voltage and consequently changes conformation to cause large cell length changes, termed electromotility (eM). In OHCs studied in vitro, the prestin
arxiv +1 more source