Results 41 to 50 of about 38,853 (217)

Microstructural interactions contribute to the hotspot in the living cochlea

Current Research in Neurobiology, 2022
The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration “hotspot” was recently observed in the high-frequency region of the living gerbil cochlea between the ...
Junpei Liu, Yanru Bai, Qianli Cheng, Shu Zheng, Stephen Elliott, Guangjian Ni   +5 more
doaj   +1 more source

Aminoglycoside-Induced Phosphatidylserine Externalization in Sensory Hair Cells Is Regionally Restricted, Rapid, and Reversible [PDF]

, 2008
The aminophospholipid phosphatidylserine (PS) is normally restricted to the inner leaflet of the plasma membrane. During certain cellular processes, including apoptosis, PS translocates to the outer leaflet and can be labeled with externally applied ...
Gale, Jonathan E, Goodyear, Richard J, Kros, Corné J, Ranatunga, Kishani M, Richardson, Guy P   +4 more
core   +1 more source

In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]

, 2017
We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo, Chiorini, John A., Crispino, Giulia, Di Pasquale, Giovanni, Galindo Ramirez, Fabian, Mammano, Fabio, Praetorius, Mark, Zorzi, Veronica   +7 more
core   +1 more source

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

The Study of Otoacoustic Emissions and the Suppression of Otoacoustic Emissions in Subjects with Tinnitus and Normal Hearing: An Insight to Tinnitus Etiology

International Archives of Otorhinolaryngology, 2015
Introduction Analysis of the suppression effect is a simple method to evaluate cochlear status and central auditory mechanisms and, more specifically, the medial olivocochlear system.
Lucieny Serra, Gabriela Novanta, Andre Lopes Sampaio, Carlos Augusto Oliveira, Ronaldo Granjeiro, Silvia Cristina Braga   +5 more
doaj   +1 more source

Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells

BMJ Open Diabetes Research & Care, 2020
ObjectiveThe mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to ...
Ann-Ki Pålbrink, Franziska Kopietz, Björn Morén, René In 't Zandt, Federico Kalinec, Karin Stenkula, Olga Göransson, Cecilia Holm, Måns Magnusson, Eva Degerman   +9 more
doaj   +1 more source

Metabolic Abnormalities Linked to Auditory Pathways in ApoE-Knockout HEI-OC1 Cells: A Transcription-Metabolism Co-Analysis

Biomolecules, 2022
Lipid transporter protein apolipoprotein E (APOE) has contributed to functional studies of various organ functions. Animals with ApoE knockout (KO) have been used to study atherosclerosis and hyperlipidemia while an increasing number of researchers have ...
Lu Ma, Hongshun Wang, Jun Yao, Qinjun Wei, Xin Cao   +4 more
doaj   +1 more source

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing [PDF]

, 2010
Publisher version: http://www.nature.com/embor/journal/v11/n10/full/embor2010135.htmlDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA - ENG PT - JOURNAL ARTICLEDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA ...
Alexandra E Porter, Anil Lalwani, Carol G Chen, Currey JD, Delia S Brauer, Emily N Chin, Filvaroff E, Grayson W Marshall, Guive Balooch, Higashi K, Jacob Johnson, Jolie L Chang, Kristin Butcher, Lawrence Lustig, Mary Beth Humphrey, Omar Akil, Richard A Schneider, Rik Derynck, Robert O Ritchie, Sally J Marshall, Sorensen MS, Tamara Alliston   +21 more
core   +1 more source

Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice. [PDF]

PLoS ONE, 2015
Mutations in GJB2, which encodes connexin 26 (Cx26), a cochlear gap junction protein, represent a major cause of pre-lingual, non-syndromic deafness. The degeneration of the organ of Corti observed in Cx26 mutant-associated deafness is thought to be a ...
Takashi Anzai, Ichiro Fukunaga, Kaori Hatakeyama, Ayumi Fujimoto, Kazuma Kobayashi, Atena Nishikawa, Toru Aoki, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda, Kazusaku Kamiya   +10 more
doaj   +1 more source

The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15 [PDF]

, 2006
Sound and acceleration are detected by hair bundles, mechanosensory structures located at the apical pole of hair cells in the inner ear. The different elements of the hair bundle, the stereocilia and a kinocilium, are interconnected by a variety of link
Ahmed, Zubair M, Behra, Martine, Belyantseva, Inna A, Burgess, Shawn M, Friedman, Thomas B, Frolenkov, Gregory I, Goodyear, Richard, Griffith, Andrew J, Lagziel, Ayala, Legan, P Kevin, Lilley, Kathryn S, Riazuddin, Saima, Riazuddin, Sheikh, Richardson, Guy P, Wilcox, Edward R   +14 more
core   +2 more sources