Results 51 to 60 of about 38,316 (263)

Inner ear is a target for insulin signaling and insulin resistance: evidence from mice and auditory HEI-OC1 cells

BMJ Open Diabetes Research & Care, 2020
ObjectiveThe mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to ...
Ann-Ki Pålbrink, Franziska Kopietz, Björn Morén, René In 't Zandt, Federico Kalinec, Karin Stenkula, Olga Göransson, Cecilia Holm, Måns Magnusson, Eva Degerman   +9 more
doaj   +1 more source

Metabolic Abnormalities Linked to Auditory Pathways in ApoE-Knockout HEI-OC1 Cells: A Transcription-Metabolism Co-Analysis

Biomolecules, 2022
Lipid transporter protein apolipoprotein E (APOE) has contributed to functional studies of various organ functions. Animals with ApoE knockout (KO) have been used to study atherosclerosis and hyperlipidemia while an increasing number of researchers have ...
Lu Ma, Hongshun Wang, Jun Yao, Qinjun Wei, Xin Cao   +4 more
doaj   +1 more source

Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice. [PDF]

PLoS ONE, 2015
Mutations in GJB2, which encodes connexin 26 (Cx26), a cochlear gap junction protein, represent a major cause of pre-lingual, non-syndromic deafness. The degeneration of the organ of Corti observed in Cx26 mutant-associated deafness is thought to be a ...
Takashi Anzai, Ichiro Fukunaga, Kaori Hatakeyama, Ayumi Fujimoto, Kazuma Kobayashi, Atena Nishikawa, Toru Aoki, Tetsuo Noda, Osamu Minowa, Katsuhisa Ikeda, Kazusaku Kamiya   +10 more
doaj   +1 more source

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing [PDF]

, 2010
Publisher version: http://www.nature.com/embor/journal/v11/n10/full/embor2010135.htmlDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA - ENG PT - JOURNAL ARTICLEDA - 20100917 IS - 1469-3178 (Electronic) IS - 1469-221X (Linking) LA ...
Alexandra E Porter, Anil Lalwani, Carol G Chen, Currey JD, Delia S Brauer, Emily N Chin, Filvaroff E, Grayson W Marshall, Guive Balooch, Higashi K, Jacob Johnson, Jolie L Chang, Kristin Butcher, Lawrence Lustig, Mary Beth Humphrey, Omar Akil, Richard A Schneider, Rik Derynck, Robert O Ritchie, Sally J Marshall, Sorensen MS, Tamara Alliston   +21 more
core   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation.

Frontiers in Aging Neuroscience, 2015
The innervation of the inner ear critically depends on the two neurotrophins Ntf3 and Bdnf. In contrast to this molecularly well established dependency, evidence regarding the need of innervation for long-term maintenance of inner ear hair cells is ...
Jennifer eKersigo, Bernd eFritzsch
doaj   +1 more source

Fas Ligand Expression in the Organ of Corti [PDF]

Audiology and Neurotology, 2003
We have previously demonstrated by FACS analysis and histochemistry that Fas ligand (FasL) increases on cochlear cell surfaces after immune response or stimulation with γ-interferon (IFN-γ). To determine whether the appearance of FasL on cochlear cell membranes is related to gene expression or to posttranslational events, cochlear cells were treated ...
Bodmer, Daniel, Brors, Dominik, Bodmer, Morana, Pak, Kwang, Ryan, Allen F.   +4 more
openaire   +4 more sources

Speech Recognition with Cochlea‐Inspired In‐Sensor Computing

Advanced Intelligent Systems, EarlyView.
Traditional speech recognition methods rely on software‐based feature extraction that introduces latency and high energy costs, making them unsuitable for low‐power devices. A proof‐of‐concept demonstration is provided of a bioinspired tonotopic sensor for speech recognition that mimics the human cochlea, using a spiral‐shaped elastic metamaterial. The
Paolo H. Beoletto, Gianluca Milano, Carlo Ricciardi, Federico Bosia, Antonio S. Gliozzi   +4 more
wiley   +1 more source

Cochlear duct length along the outer wall vs organ of corti: Which one is relevant for the electrode array length selection and frequency mapping using Greenwood function?

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2019
Cochlear duct length (CDL) measurement or estimation is a hot topic for various research groups in the cochlear implant (CI) field as of today. Getting the CDL along the outer wall (LW) and organ of corti (OC) is possible but considering the clinical ...
Anandhan Dhanasingh
doaj   +1 more source

Functional anatomy of the middle and inner ears of the red fox, in comparison to domestic dogs and cats

, 2020
Anatomical middle and inner ear parameters are often used to predict hearing sensitivities of mammalian species. Given that ear morphology is substantially affected both by phylogeny and body size, it is interesting to consider whether the relatively ...
Burda, H., Malkemper, E., Mason, M.
core   +1 more source