Results 51 to 60 of about 17,899 (265)
Frontiers in Genetics, 2018 The mammalian hearing organ is a regular array of two types of hair cells (HCs) surrounded by six types of supporting cells. Along the tonotopic axis, this conserved radial array of cell types shows longitudinal variations to enhance the tuning ...
K. Booth +4 more
semanticscholar +1 more source
Force Transmission in the Organ of Corti Micromachine [PDF]
Biophysical Journal, 2010 Auditory discrimination is limited by the performance of the cochlea whose acute sensitivity and frequency tuning are underpinned by electromechanical feedback from the outer hair cells. Two processes may underlie this feedback: voltage-driven contractility of the outer hair cell body and active motion of the hair bundle.
Robert Fettiplace, Jong-Hoon Nam
openaire +3 more sources
Journal of Cellular and Molecular Medicine, 2018 Serine/threonine kinase 33 (STK33), a member of the calcium/calmodulin‐dependent kinase (CAMK), plays vital roles in a wide spectrum of cell processes. The present study was designed to investigate whether STK33 expressed in the mammalian cochlea and, if
Meijuan Zhou +10 more
semanticscholar +1 more source
International Archives of Otorhinolaryngology, 2015 Introduction Analysis of the suppression effect is a simple method to evaluate cochlear status and central auditory mechanisms and, more specifically, the medial olivocochlear system.
Lucieny Serra +5 more
doaj +1 more source
BMJ Open Diabetes Research & Care, 2020 ObjectiveThe mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to ...
Ann-Ki Pålbrink +9 more
doaj +1 more source
Biomolecules, 2022 Lipid transporter protein apolipoprotein E (APOE) has contributed to functional studies of various organ functions. Animals with ApoE knockout (KO) have been used to study atherosclerosis and hyperlipidemia while an increasing number of researchers have ...
Lu Ma +4 more
doaj +1 more source
Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice. [PDF]
PLoS ONE, 2015 Mutations in GJB2, which encodes connexin 26 (Cx26), a cochlear gap junction protein, represent a major cause of pre-lingual, non-syndromic deafness. The degeneration of the organ of Corti observed in Cx26 mutant-associated deafness is thought to be a ...
Takashi Anzai +10 more
doaj +1 more source
Advanced Science, EarlyView.This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley +1 more source
Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation.
Frontiers in Aging Neuroscience, 2015 The innervation of the inner ear critically depends on the two neurotrophins Ntf3 and Bdnf. In contrast to this molecularly well established dependency, evidence regarding the need of innervation for long-term maintenance of inner ear hair cells is ...
Jennifer eKersigo, Bernd eFritzsch
doaj +1 more source
Finite-element model of the active organ of Corti
Journal of the Royal Society Interface, 2016 The cochlear amplifier that provides our hearing with its extraordinary sensitivity and selectivity is thought to be the result of an active biomechanical process within the sensory auditory organ, the organ of Corti.
G. Ni, S. Elliott, J. Baumgart
semanticscholar +1 more source