Biology Open, 2015 Immunoglobulin-like domain containing receptor 1 (ILDR1) is a poorly characterized gene that was first identified in lymphoma cells. Mutations in ILDR1 are responsible for DFNB42, but the pathogenesis of hearing loss caused by ILDR1 mutations remains to ...
Qing Sang +9 more
doaj +1 more source
Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear. [PDF]
PLoS ONE, 2014 Sensory nerves of the brainstem are mostly composed of placode-derived neurons, neural crest-derived neurons and neural crest-derived Schwann cells. This mixed origin of cells has made it difficult to dissect interdependence for fiber guidance. Inner ear-
YanYan Mao +3 more
doaj +1 more source
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]
, 2006 The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C. +9 more
core +1 more source
Delivery strategies of messenger RNA therapeutics for brain disorders
Bulletin of the Korean Chemical Society, EarlyView.Thus, mRNA therapeutics offer a powerful new avenue for the treatment of brain diseases. This review examines strategies to bypass biological barriers, particularly the blood–brain barrier, and explores emerging delivery systems, such as direct intracerebral injection, intracerebroventricular injection, systemic delivery (including intravenous ...
Kounghwa Youn +5 more
wiley +1 more source
Use of scanning electron microscopy in the cochlea of guinea pigs
Brazilian Journal of Otorhinolaryngology, 2020 Introduction: The use of electron microscopy in the study of the inner ear has allowed us to observe minute details of the hair cells, especially in ototoxicity studies; however, the preparation of this material is a difficult and delicate task.
Luiz César Nakao Iha +1 more
doaj +1 more source
Behavioral characteristics in sensing mechanism of the Corti
Computational and Structural Biotechnology Journal, 2023 Some experiments can’t be realized because the cochlea’s Corti is the most delicate and complex sensory organ. In this paper, some typical and special behavioral characteristics in the process of sensation were found in medical clinic.
Junyi Liang +4 more
doaj +1 more source
Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses [PDF]
, 2012 BACKGROUND AND PURPOSEExposure to an ototoxic level of an aminoglycoside can result in hearing loss. In this we study investigated the otoprotective efficacy of dexamethasone (DXM), melatonin (MLT) and tacrolimus (TCR) in gentamicin (GM)-treated animals ...
Bas, E +7 more
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Circularly Polarized Near‐Infrared Electroluminescence from Chromium(III) Complex‐Based OLEDs
Small, EarlyView.Electroluminescence is developed from a chromium(III) complex, showing near‐infrared circularly polarized emission at 726 and 747 nm. This highlights the promise of earth‐abundant chromium(III) complexes for advanced chiral optoelectronic applications in fields like medicine, security, and quantum communications. Abstract Organic light‐emitting diodes (
Maxime Poncet +6 more
wiley +1 more source
Ultrastructure of the organ of Corti in harbor seals (Phoca vitulina)
Frontiers in Marine Science, 2023 Ultrastructural descriptions of the inner ear of highly sound-dependent mammalian species are lacking and needed to gain a better understanding of the hearing sense.
Laura Rojas +8 more
doaj +1 more source
Development of the stria vascularis and potassium regulation in the human fetal cochlea : insights into hereditary sensorineural hearing loss [PDF]
, 2015 Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression
Chuva de Sousa Lopes, Susana Marina +5 more
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