Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery +43 more
wiley +1 more source
Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea
Background Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss.
Haddad Luciana A +6 more
doaj +1 more source
Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core +1 more source
RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors [PDF]
Background: Insulin-like growth factor-I (IGF-I) provides pivotal cell survival and differentiation signals during inner ear development throughout evolution.
Hortensia Sanchez-Calderon +6 more
core +7 more sources
A large‐scale citizen science study involving thousands of cowslip (Primula veris) observations from all over Europe revealed an unexpected prevalence of S‐morphs over L‐morphs, which was influenced by climatic as well as land use factors. Furthermore, general morph ratios were often unbalanced with the strongest shifts occurring in smaller populations.
Tsipe Aavik +40 more
wiley +1 more source
Static length changes of cochlear outer hair cells can tune low-frequency hearing.
The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
doaj +1 more source
Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems [PDF]
Our previous work identified E3 ubiquitin ligases, termed UBR1-UBR7, that contain the ~70-residue UBR box, a motif important for the targeting of N-end rule substrates.
Hellweg, Rainer +6 more
core +1 more source
Chronic low‐concentration lead exposure accelerates the development of ARHL. Lead exposure mediates damage to cochlear sensory cells via the mitochondrial protease LONP1, leading to irreversible hearing loss. ABSTRACT Heavy metal ion exposure has become a global public health concern.
Xue Bai +10 more
wiley +1 more source
Expression of S100β during mouse cochlear development
In the present study, the expression of S100β was examined in the mouse cochlea from embryonic day 17 (E17) to postnatal day 32 (P32) using immunofluorescence, aiming to explore its possible role in auditory system.
Wenjing Liu +3 more
doaj +1 more source
Minimal basilar membrane motion in low-frequency hearing [PDF]
Low-frequency hearing is critically important for speech and music perception, but no mechanical measurements have previously been available from inner ears with intact low-frequency parts. These regions of the cochlea may function in ways different from
Ciganovic, N +10 more
core +1 more source

