Results 81 to 90 of about 2,755,367 (283)
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source
Cochlear Wave Propagation and Dynamics in the Human Base and Apex: Model-Based Estimates from Noninvasive Measurements [PDF]
AIP Conference Proceedings, vol. 3062, no. 1. AIP Publishing, 2024Cochlear wavenumber and impedance are mechanistic variables that encode information regarding how the cochlea works - specifically wave propagation and Organ of Corti dynamics. These mechanistic variables underlie interesting features of cochlear signal processing such as its place-based wavelet analyzers, dispersivity and high-gain.
arxiv +1 more source
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]
, 2017 We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo +7 more
core +1 more source
Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, EarlyView.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Temporal coherence and correlation of counterpropagating twin photons [PDF]
A.Gatti, T. Corti and E. Brambilla, Phys. Rev. A 96, 013820, 2017, 2015 This work analyses the temporal coherence and correlation of counterpropagating twin photons generated in a quasi-phase matched nonlinear cristal by spontaneous parametric-down conversion. We find out different pictures depending on the pump pulse duration relative to two characteristic temporal scales, determined respectively by the temporal ...
arxiv +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Expression of S100β during mouse cochlear development
European Journal of HistochemistryIn the present study, the expression of S100β was examined in the mouse cochlea from embryonic day 17 (E17) to postnatal day 32 (P32) using immunofluorescence, aiming to explore its possible role in auditory system.
Wenjing Liu +3 more
doaj +1 more source
Static length changes of cochlear outer hair cells can tune low-frequency hearing.
PLoS Computational Biology, 2018 The cochlea not only transduces sound-induced vibration into neural spikes, it also amplifies weak sound to boost its detection. Actuators of this active process are sensory outer hair cells in the organ of Corti, whereas the inner hair cells transduce ...
Nikola Ciganović +5 more
doaj +1 more source
A Physical Model for Self-Similar Seashells [PDF]
arXiv, 2019 This paper presents a simple physical model for self-similar (gnomonic, or first-order) seashell growth which is expressed in coordinate-free terms. The shell is expressed as the solution of a differential equation which expresses the growth dynamics, and may be used to investigate shell growth from both the local viewpoint of the organism building it ...
arxiv