Results 121 to 130 of about 108,308 (280)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Mitochondrial adventures at the organelle society

, 2018
Mitochondria are constantly communicating with the rest of the cell. Defects in mitochondria underlie severe pathologies, whose mechanisms remain poorly understood.
Nuno Raimundo, Yambire, King Faisal, Raimundo, Nuno, Branco F., Tiago, Cátia V. Diogo, Tiago Branco F., King Faisal Yambire, Lorena Fernández Mosquera, Fernández Mosquera, Lorena, Diogo, Cátia V.   +9 more
core   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Centriole Biogenesis: From Identifying the Characters to Understanding the Plot

, 2017
The centriole is a beautiful microtubule-based organelle that is critical for the proper execution of many fundamental cellular processes, including polarity, motility, and division.
Pierre Gönczy, Niccolò Banterle
core   +1 more source

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Organelle Size Scaling of the Budding Yeast Vacuole by Relative Growth and Inheritance [PDF]

, 2016
It has long been noted that larger animals have larger organs compared to smaller animals of the same species, a phenomenon termed scaling [1]. Julian Huxley proposed an appealingly simple model of "relative growth"-in which an organ and the whole body ...
Chan, Yee-Hung M, Marshall, Wallace F, Reyes, Lorena, Tran, Nancy K, Sohail, Saba M   +4 more
core   +1 more source

Cloning and characterisation of SSV genes from Saccharomyces Cerevisiae [PDF]

, 1995
In order to investigate the pleiotropic effects exhibited by mutations of S. cerevisiae defective in genes involved in vacuole biogenesis, a number of mutants were chosen for further study.
Hartley, Caroline Anne
core  

Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics. [PDF]

Elife, 2021
Mofatteh M, Echegaray-Iturra F, Alamban A, Dalla Ricca F, Bakshi A, Aydogan MG.   +5 more
europepmc   +1 more source

Characterisation of Pex30-family proteins in organelle biogenesis and membrane contact sites

Membrane lipids and proteins produced in the endoplasmic reticulum (ER) are used for the de novo assembly of organelles, such as lipid droplets (LDs) and peroxisomes. After assembly, the growth and function of these organelles are supported by ER-derived
Verissimo Ferreira, Joana
core   +1 more source