Results 101 to 110 of about 108,308 (280)

ABCD Meeting “Organelle Biogenesis and Signal Transduction”

, 2016
An ubiquitin-proteasome-endocytic pathway but not autophagy orchestrates ErbB2 internalization and cleavage in HSP90-inhibited breast cancer ...
Cortese K., Birocchi F, Castagnola P, Tacchetti C, Bellese G, Gagliani MC   +5 more
core  

Participation of non-coding RNAs in plant organelle biogenesis

, 2016
The biogenesis of plant mitochondria and plastids is a multistep process that depends on the expression of both, organellar and nuclear genes. A growing body of evidence suggests that the indispensable coordination of different steps in this process may ...
Rurek, Michal
core   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Synchronous spatiotemporal control of autophagy and organelle trafficking is necessary for infection by Magnaporthe oryzae

Cell Reports
Summary: The blast fungus Magnaporthe oryzae infects plants using an appressorium that generates force to breach the leaf cuticle. Appressorium development follows a cell-cycle-regulated morphogenetic program requiring autophagy-associated death of the ...
Alice B. Eseola, Xia Yan, Lauren S. Ryder, Miriam Osés-Ruiz, Martin J. Egan, Dan MacLean, Nicholas J. Talbot   +6 more
doaj   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Phosphatidylinositol 3-monophosphate is involved in Toxoplasma apicoplast biogenesis [PDF]

, 2011
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Henri J Vial, Dubremetz, J.-F., Payrastre, B., Merezegue, F., Montcourrier, Philippe, Merezegue, Fabrice, Jean-François Dubremetz, Tawk, Lina, Payrastre Bernard, Chicanne Gaëtan, Payrastre, Bernard, Roy Christian, Philippe Montcourrier, Lebrun Maryse, Vial, H.J., Vial Henri J., Véronique Richard, Henri J. Vial, Roy, C., Dubremetz Jean-François, Markus Meissner, Lebrun, M., Chicanne, G., Kai Wengelnik, Wengelnik Kai, Christian Roy, Wengelnik, Kai, Lina Tawk, Chicanne, Gaëtan, Montcourrier Philippe, Lebrun, Maryse, Bernard Payrastre, Vial, Henri, Roy, Christian, Fabrice Merezegue, Richard, V., Meissner, M., Meissner Markus, Richard Véronique, Tawk, L., Meissner, Markus, Gaëtan Chicanne, Maryse Lebrun, Tawk Lina, Merezegue Fabrice, Dubremetz, Jean-François, Wengelnik, K., Montcourrier, P., Richard, Véronique   +48 more
core   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

De novo organelle biogenesis in the cyanobacterium TDX16 released from the green algaHaematococcus pluvialis

, 2017
It is believed that eukaryotes arise from prokaryotes, which means that organelles can form in the latter. Such events, however, had not been observed previously. Here, we report the biogenesis of organelles in the endosymbiotic cyanobacterium TDX16 that
Xiao-lin Wei, Xiang-ying Xing, Shuo Zhang, Yang Han, Qing-lin Dong   +4 more
core   +1 more source

The gateway to chloroplast: re-defining the function of chloroplast receptor proteins [PDF]

, 2012
Chloroplast biogenesis often requires a tight orchestration between gene expression (both plastidial and nuclear) and translocation of similar to 3000 nuclear-encoded proteins into the organelle.
Bölter, Bettina, Soll, Jürgen, Chang, Wai-Ling   +2 more
core   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source