Results 81 to 90 of about 108,308 (280)

The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice

eLife, 2023
The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by a ...
Ke Xu, Xianwei Su, Kailun Fang, Yue Lv, Tao Huang, Mengjing Li, Ziqi Wang, Yingying Yin, Tahir Muhammad, Shangming Liu, Xiangfeng Chen, Jing Jiang, Jinsong Li, Wai-Yee Chan, Jinlong Ma, Gang Lu, Zi-Jiang Chen, Hongbin Liu   +17 more
doaj   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

PHOTOCONTROL OF ORGANELLE BIOGENESIS IN Euglena [PDF]

Photochemistry and Photobiology, 1990
The purpose of this review is to summarize recent work on the photocontrol of chloroplast, mitochondrial and microbody biogenesis in Euglena in the context of light being one of a number of potential sources of carbon and energy for ...
openaire   +1 more source

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]

, 2007
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett, Carsten Wrenger, Gunther, M, Storm Janet, McMillan, Paul, Günther, S, Müller, S, Wallace, L., Muller, S., Patzewitz, Eva-Maria, Paul J McMillan, Lynsey Wallace, Wrenger, C., Günther, S., Bissett Ryan, Wrenger, Carsten, Smith, T.K., Muller, Sylke, McMillan Paul J, Bissett, Ryan, Guenther, Svenja, McMillan, Paul J., Smith, Terry, Sylke Müller, Patzewitz, E.-M., Terry K Smith, Storm, J., Günther Svenja, Storm, Janet, Svenja Günther, Patzewitz, EM, Wallace, Lynsey, Storm, J, McMillan, PJ, Patzewitz Eva-Maria, Mueller, Sylke, McMillan, P.J., Eva-Maria Patzewitz, Wallace Lynsey, Bissett, R, Wrenger, C, Janet Storm, Smith Terry K, Smith, TK, Wrenger Carsten, Smith, Terry K, Wallace, L, Bissett, R., Müller Sylke   +48 more
core   +1 more source

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

Nature Communications, 2018
The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 ...
Diana M. Mitrea, Jaclyn A. Cika, Christopher B. Stanley, Amanda Nourse, Paulo L. Onuchic, Priya R. Banerjee, Aaron H. Phillips, Cheon-Gil Park, Ashok A. Deniz, Richard W. Kriwacki   +9 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis

, 2010
Medema MH, Zhou M, van Hijum SAFT, et al. A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis. BMC Genomics.
Sacha A.F.T. van Hijum, Gloerich, J., Zhou, M., Wessels, Hans J. C. T, Strous Marc, Wessels Hans JCT, Jolein Gloerich, Strous, Marc, Medema, M.H., Gloerich Jolein, Marc Strous, van Hijum, Sacha A. F. T., van Hijum Sacha AFT, Gloerich, Jolein, Zhou Miaomiao, Siezen Roland J, Siezen, Roland J., Strous, M., Hans J.C.T Wessels, Hijum, S.A.F.T. van, Roland J. Siezen, Wessels, H.C.T., Medema, Marnix H., Marnix H. Medema, Siezen, R.J., Zhou, Miaomiao, Miaomiao Zhou, Medema Marnix H   +27 more
core   +1 more source